The Implication of Neuroactive Steroids in Tourette's Syndrome Pathogenesis: A Role for 5α-Reductase?

June 2013 in “ Journal of neuroendocrinology ”

Marco Bortolato, Roberto Frau, Sean C. Godar, Laura J. Mosher, S Paba, Francesco Marrosu, Paola Devoto

neuroactive steroids 5α-reductase Tourette's Syndrome tics genetic factors neurobiological factors environmental factors

Studysummary This research observed that 5α-reductase inhibitors showed significant tic-suppressing effects in Tourette's syndrome, suggesting a key role for this enzyme in the disorder's pathogenesis.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The document discussed the potential role of neuroactive steroids, particularly focusing on the enzyme 5α-reductase, in the pathogenesis of Tourette's Syndrome (TS). It reviewed various studies suggesting that alterations in neuroactive steroid levels might influence the severity and expression of tics in TS. The paper highlighted the complexity of TS, involving genetic, neurobiological, and environmental factors, and suggested that targeting neuroactive steroid pathways could offer new therapeutic approaches for managing TS symptoms.

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