The Implication of Neuroactive Steroids in Tourette's Syndrome Pathogenesis: A Role for 5α-Reductase?

    June 2013 in “ Journal of neuroendocrinology ”
    Marco Bortolato, Roberto Frau, Sean C. Godar, Laura J. Mosher, S Paba, Francesco Marrosu, Paola Devoto
    TLDR Neuroactive steroids and the enzyme 5α-reductase might be involved in the development of Tourette's syndrome.
    The document discussed the potential role of neuroactive steroids, particularly focusing on the enzyme 5α-reductase, in the pathogenesis of Tourette's Syndrome (TS). It reviewed various studies suggesting that alterations in neuroactive steroid levels might influence the severity and expression of tics in TS. The paper highlighted the complexity of TS, involving genetic, neurobiological, and environmental factors, and suggested that targeting neuroactive steroid pathways could offer new therapeutic approaches for managing TS symptoms.
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