TLDR Neuroactive steroids and the enzyme 5α-reductase might be involved in the development of Tourette's syndrome.
The document discussed the potential role of neuroactive steroids, particularly focusing on the enzyme 5α-reductase, in the pathogenesis of Tourette's Syndrome (TS). It reviewed various studies suggesting that alterations in neuroactive steroid levels might influence the severity and expression of tics in TS. The paper highlighted the complexity of TS, involving genetic, neurobiological, and environmental factors, and suggested that targeting neuroactive steroid pathways could offer new therapeutic approaches for managing TS symptoms.
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134 citations
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August 2012 in “The Journal of Clinical Psychiatry” Former finasteride users with persistent sexual side effects have higher rates of depression and suicidal thoughts.
35 citations
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June 2012 in “Journal of Clinical Psychopharmacology” Finasteride reduces gambling symptoms in Parkinson's patients.
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September 2011 in “Movement Disorders” Finasteride reduces Tourette syndrome symptoms, but results may be limited due to potential biases.
185 citations
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June 2011 in “The Journal of Sexual Medicine” Finasteride for hair loss can cause long-lasting sexual side effects like low libido and erectile dysfunction.
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March 2011 in “The Journal of Sexual Medicine” Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.
72 citations
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January 2011 in “Current Pharmaceutical Design” S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.
42 citations
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December 2007 in “American Journal of Psychiatry” Finasteride may effectively reduce Tourette's syndrome symptoms and improve life quality.
