5alpha-Reductase Inhibitors Dampen L-DOPA-Induced Dyskinesia via Normalization of Dopamine D1-Receptor Signaling Pathway and D1-D3 Receptor Interaction

    September 2018 in “ Neurobiology of Disease ”
    Silvia Fanni, Simona Scheggi, Francesca Rossi … Manolo Carta
    Studysummary This study found that both finasteride and dutasteride significantly reduced L-DOPA-induced dyskinesia in a rat model of Parkinson's disease, with dutasteride showing greater effectiveness at lower doses.
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    Research cited in this study 13

    1. The 5-Alpha Reductase Inhibitor Finasteride Reduces Dyskinesia in a Rat Model of Parkinson’s Disease Experimental Neurology · 2017
    2. The Neurosteroidogenic Enzyme 5α-Reductase Modulates the Role of D1 Dopamine Receptors in Rat Sensorimotor Gating Psychoneuroendocrinology · 2015
    3. Targeting Neurosteroid Synthesis as a Therapy for Schizophrenia-Related Alterations Induced by Early Psychosocial Stress Schizophrenia Research · 2015
    4. Inhibition Of 5α-Reductase Attenuates Behavioral Effects Of D1-, But Not D2-Like Receptor Agonists In C57BL/6 Mice Psychoneuroendocrinology · 2012
    5. Finasteride Attenuates Pathological Gambling in Patients With Parkinson's Disease Journal of Clinical Psychopharmacology · 2012
    6. Inhibition of 5α-Reductase in the Nucleus Accumbens Counters Sensorimotor Gating Deficits Induced by Dopaminergic Activation Psychoneuroendocrinology · 2011
    7. A Preliminary Study of Finasteride in Tourette Syndrome Movement Disorders · 2011
    8. Steroid 5α-Reductase as a Novel Therapeutic Target for Schizophrenia and Other Neuropsychiatric Disorders Current Pharmaceutical Design · 2011
    9. Treatment of Benign Essential Blepharospasm With Finasteride Clinical Neuropharmacology · 2010
    10. An Overview on 5α-Reductase Inhibitors Steroids · 2009
    11. Key Targets of Hormonal Treatment of Prostate Cancer: The Androgen Receptor and 5α-Reductase BJU international · 2009
    12. Antipsychotic-Like Properties of 5-Alpha-Reductase Inhibitors Neuropsychopharmacology · 2008
    13. Treatment of Tourette’s Syndrome With Finasteride American Journal of Psychiatry · 2007