Post-Finasteride Syndrome

    August 2019 in “ BMJ ”
    Shelly L. Gray, Todd P. Semla
    Image of study
    TLDR Post-finasteride syndrome causes sexual, physical, and psychological symptoms, but more research is needed to understand its causes and connection to finasteride.
    Post-finasteride syndrome is a controversial syndrome associated with a range of sexual, physical, and psychological symptoms that develop during or after finasteride exposure and persist after discontinuation. The incidence of post-finasteride syndrome is unknown, as are the biological mechanisms, but it is known that 5a-reductase inhibitors reduce synthesis of brain neurosteroids, which affect mood, cognition, and libido. The evidence for a causal link between finasteride and persistent symptoms is low quality, and safety reporting has been inadequate in clinical trials of 5a-reductase inhibitors. More research is needed to understand the biological underpinnings of post-finasteride syndrome and to determine whether patient reports of persistent symptoms are caused by finasteride.
    Discuss this study in the Community →

    Research cited in this study

    10 / 10 results

    Related Community Posts Join

    6 / 1000+ results

      community Just popped my first fin, excited as hell!

      in Finasteride/Dutasteride  154 upvotes 1 year ago
      A user shared their excitement about starting finasteride for hair loss after trying various ineffective methods. Other users discussed their experiences with finasteride, including shedding phases and side effects, with one mentioning using topical finasteride and minoxidil.

      community DHT and 5AR respect post, it's importance within the brain

      in Research/Science  111 upvotes 2 years ago
      The conversation discusses whether to use finasteride for hair loss, considering its role in inhibiting DHT and 5AR, which can affect brain function and mood. Some users report anxiety and depression from finasteride, while others do not experience these side effects and emphasize the importance of DHT for brain and prostate health.

      community Finasteride does deplete important nuero-active steroids

      in Research/Science  9 upvotes 2 years ago
      Finasteride can reduce neuroactive steroids, causing side effects like depression, anxiety, and sexual dysfunction. Some users experience persistent symptoms after stopping finasteride, while others use alternative treatments like topical solutions.

      community Why is Kevin Mann (Haircafe) Hated?

      in Chat  62 upvotes 2 years ago
      Hair loss treatments, including microneedling, minoxidil, finasteride and RU58841; the efficacy of these treatments; criticisms of Kevin Mann's content related to his selective data presentation and biases towards certain treatments; and other topics such as DHT being labeled a "trash hormone" and critiques of other hairloss YouTubers.

      community Spironolactone for 11 years, finasteride for almost 5 years, started oral minoxidil in November 😢 ended oral contraceptive in Dec.

      in Progress Pictures  224 upvotes 1 year ago
      A user shared their 11-year experience with spironolactone and nearly 5 years with finasteride for hair loss, recently adding oral minoxidil and stopping birth control. Various treatments were discussed, including organic options, checking for underlying health issues, considering dutasteride, and the potential role of progesterone in hair loss.

      community Proof that finasteride messes with neurosteroids

      in Research/Science  230 upvotes 1 year ago
      Finasteride can impact neurosteroids, potentially causing depression and other side effects in some users. Despite these concerns, many continue using it for hair loss, with some switching to topical applications to mitigate side effects.

    Related Research

    2 / 2 results