A Review of the FAERS Data on 5-Alpha Reductase Inhibitors: Implications for Postfinasteride Syndrome

    June 2018 in “ Urology ”
    Wesley Baas, Michael Butcher, Aye Aye Lwin … Kevin T. McVary
    Studysummary This study of FAERS data suggests that finasteride, particularly at the 1 mg dosage, is associated with a wide range of adverse effects not previously established in long-term studies, especially among younger men.
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    Research cited in this study 16

    1. Persistent Sexual Dysfunction with Finasteride 1 mg Taken for Hair Loss Pharmacotherapy · 2016
    2. Adverse Event Reporting in Clinical Trials of Finasteride for Androgenic Alopecia: A Meta-Analysis PubMed · 2015
    3. Persistent Sexual, Emotional, and Cognitive Impairment Post-Finasteride American Journal of Men's Health · 2014
    4. Neuroactive Steroid Levels Are Modified in Cerebrospinal Fluid and Plasma of Post-Finasteride Patients Showing Persistent Sexual Side Effects and Anxious/Depressive Symptomatology The Journal of Sexual Medicine · 2013
    5. The Efficacy and Safety of 5α-Reductase Inhibitors in Androgenetic Alopecia: A Network Meta-Analysis and Benefit–Risk Assessment of Finasteride and Dutasteride Journal of Dermatological Treatment · 2013
    6. Depressive Symptoms and Suicidal Thoughts Among Former Users of Finasteride With Persistent Sexual Side Effects The Journal of Clinical Psychiatry · 2012
    7. Persistent Sexual Side Effects of Finasteride: Could They Be Permanent? The Journal of Sexual Medicine · 2012
    8. The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases Advances in Urology · 2011
    9. Adverse Side Effects of 5α-Reductase Inhibitors Therapy: Persistent Diminished Libido, Erectile Dysfunction, and Depression in a Subset of Patients The Journal of Sexual Medicine · 2010
    10. Finasteride-Induced Depression: New Insights Into Possible Pathomechanisms Journal of Cosmetic Dermatology · 2010
    11. Finasteride Treatment Inhibits Adult Hippocampal Neurogenesis in Male Mice Pharmacopsychiatry · 2010
    12. Finasteride 5mg and Sexual Side Effects: How Many Are Related to a Nocebo Phenomenon? The Journal of Sexual Medicine · 2007
    13. Finasteride Induced Depression: A Prospective Study BMC clinical pharmacology · 2006
    14. Neurosteroids, Neuroactive Steroids, and Symptoms of Affective Disorders Pharmacology, Biochemistry and Behavior · 2006
    15. Psychological Aspects of Hair Disease Journal of cosmetic dermatology · 2005
    16. Depression Related to Finasteride Administration for Androgenetic Alopecia Journal of Dermatology · 2002

    Related research 6

    1. Evaluation of the Therapeutic Effects of AGA Drugs by Measuring Finasteride, Dutasteride, and Dihydrotestosterone in Hair Clinica Chimica Acta · 2023
    2. What Do We Know About 5-Alpha Reductase Inhibitors? Surgical and Cosmetic Dermatology · 2018
    3. Dutasteride in Androgenetic Alopecia: An Update Current Clinical Pharmacology · 2017
    4. Dutasteride for Men with Androgenic Alopecia Unresponsive to Finasteride Journal of Investigative Dermatology · 2016
    5. Atypical Post-Finasteride Syndrome: A Pharmacological Riddle Indian Journal of Pharmacology · 2016
    6. The Preventive and Therapeutic Efficacy of Finasteride and Dutasteride in TRAMP Mice The FASEB Journal · 2013