Investigation of Suicidality and Psychological Adverse Events in Patients Treated With Finasteride

    November 2020 in “ JAMA Dermatology ”
    David-Dan Nguyen, Maya Marchese, Eugene B. Cone … Quoc-Dien Trinh
    Studysummary This pharmacovigilance study found an increased association of suicidality and psychological adverse events with finasteride use, especially among younger patients using it for alopecia.
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    Research cited in this study 13

    1. Finasteride and Suicide: A Postmarketing Case Series Dermatology · 2020
    2. Sexual Dysfunction in Men Taking Systemic Dermatologic Medication: A Systematic Review Journal of The American Academy of Dermatology · 2019
    3. Association of Suicidality and Depression With 5α-Reductase Inhibitors JAMA Internal Medicine · 2017
    4. Sexual Side Effects of 5-Alpha-Reductase Inhibitors Finasteride and Dutasteride: A Comprehensive Review Dermatology Online Journal · 2017
    5. Characteristics of Men Who Report Persistent Sexual Symptoms After Finasteride Use for Hair Loss The Journal of Clinical Endocrinology and Metabolism · 2016
    6. Persistent Sexual Dysfunction and Suicidal Ideation in Young Men Treated with Low-Dose Finasteride: A Pharmacovigilance Study Pharmacotherapy · 2015
    7. Adverse Event Reporting in Clinical Trials of Finasteride for Androgenic Alopecia: A Meta-Analysis PubMed · 2015
    8. Depressive Symptoms and Suicidal Thoughts Among Former Users of Finasteride With Persistent Sexual Side Effects The Journal of Clinical Psychiatry · 2012
    9. Persistent Sexual Side Effects of Finasteride for Male Pattern Hair Loss The Journal of Sexual Medicine · 2011
    10. Adverse Side Effects of 5α-Reductase Inhibitors Therapy: Persistent Diminished Libido, Erectile Dysfunction, and Depression in a Subset of Patients The Journal of Sexual Medicine · 2010
    11. Finasteride Induced Depression: A Prospective Study BMC clinical pharmacology · 2006
    12. Neurosteroids, Neuroactive Steroids, and Symptoms of Affective Disorders Pharmacology, Biochemistry and Behavior · 2006
    13. Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor ˜The œJournal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 2004

    Related research 5

    1. What's New in Therapy for Male Androgenetic Alopecia? American Journal of Clinical Dermatology · 2022
    2. Investigation of Suicidality and Psychological Adverse Events in Patients Treated With Finasteride JAMA Dermatology · 2020
    3. Androgenetic Alopecia: Drug Safety and Therapeutic Strategies Expert Opinion on Drug Safety · 2018
    4. Combined Treatment of Benign Prostatic Syndrome with Tamsulosin and Finasteride: Literature Review and Prescription Data Urologe A · 2017
    5. Dutasteride Improves Hair Growth in Patients with Male Pattern Baldness More Effectively Than Finasteride Inpharma Weekly · 2007