TLDR Genetic variations greatly affect individual metabolism and can impact health and disease risk.
The study examined the genetic architecture of over 900 metabolites in nearly 20,000 individuals to understand the genetic regulation of biochemical individuality. The researchers identified 1,847 associations of 330 genomic regions with 646 metabolites and found 423 genetically influenced metabotypes (GIMs). They discovered that variation near the SRD5A2 gene, associated with male-pattern baldness, was linked with eight steroid metabolites. Two genetic variants near the SRD5A2 gene were found to alter steroid metabolism, with one variant associated with a lower risk for male-pattern baldness and another linked to an increased risk for depression. The study also identified four variants in the DPYD region, which is involved in the breakdown of certain cancer chemotherapies, and these variants were associated with higher plasma uracil levels, suggesting a potential risk of treatment-induced toxicity. The study concluded that genetic variations significantly influence metabolic individuality and have diverse health implications.
40 citations,
November 2020 in “JAMA Dermatology” Finasteride may cause suicidal thoughts and mental side effects, especially in young people with hair loss.
58 citations,
December 2018 in “Nature Communications” Male pattern baldness is mostly inherited, involves many genes, and is linked to other traits like early puberty and strong bones.
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13 citations,
August 1997 in “Steroids” Finasteride effectively lowers specific hormone levels, helping monitor treatment progress.
218 citations,
December 2011 in “Advances in Urology” The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.
35 citations,
January 2014 in “Postepy Dermatologii I Alergologii” DHT's role in hair loss is important, but measuring its level for diagnosis is questionable.
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87 citations,
March 2011 in “Australasian Journal of Dermatology” Genetics and hormones play a role in male and female hair loss, but more research is needed to fully understand it.
57 citations,
February 2007 in “International Journal of Cancer” A49T gene variant linked to higher prostate cancer risk, lower hormone levels, and slightly reduced balding risk.
50 citations,
February 2013 in “Annals of Clinical Biochemistry” Understanding how DHT works is important for diagnosing and treating hormone-related disorders.
