Rare and Common Genetic Determinants of Metabolic Individuality and Their Effects on Human Health

    November 2022 in “ Nature Medicine ”
    Praveen Surendran, Isobel D. Stewart, Victoria P W Au Yeung, Maik Pietzner, Johannes Raffler, Maria A. Wörheide, Chen Li, Rebecca F Smith, Laura B. L. Wittemans, Lorenzo Bomba, Cristina Menni, Jonas Zierer, Niccolò Rossi, Patricia A. Sheridan, Nicholas A. Watkins, Massimo Mangino, Pirro G. Hysi, Emanuele Di Angelantonio, Mario Falchi, Tim D. Spector, Nicole Soranzo, Gregory A. Michelotti, Wiebke Arlt, Luca A. Lotta, Spiros Denaxas, Harry Hemingway, Eric R. Gamazon, Joanna M.M. Howson, Angela Wood, John Danesh, Nick Wareham, Gabi Kastenmüller, Eric B. Fauman, Karsten Suhre, Adam S. Butterworth, Claudia Langenberg
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    Studysummary This study identified thousands of variant-metabolite associations in the human plasma metabolome, offering insights into the genetic bases of metabolism and potential adverse drug effects.
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