5α-Reductase Type 2 Gene Variant Associations with Prostate Cancer Risk, Circulating Hormone Levels, and Androgenetic Alopecia

November 2006 in “ International Journal of Cancer ”

Vanessa M. Hayes, Gianluca Severi, Emma J.D. Padilla, Howard R. Morris, Wayne D. Tilley, Melissa C. Southey, Dallas R. English, Robert L. Sutherland, John L. Hopper, Peter Boyle, Graham G. Giles

5α-Reductase type 2 SRD5A2 gene androgenetic alopecia A49T variant 3a-diolG circulating hormone levels androgenic alopecia

Studysummary This study found that the SRD5A2 A49T A variant is associated with an increased risk of prostate cancer, lower circulating 3α‐diolG levels, and a decreased risk of baldness.

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This study from 2007 investigated the association between genetic variants of the SRD5A2 gene and prostate cancer risk, circulating hormone levels, and androgenetic alopecia. The study found that carriers of the A49T variant had a higher risk of prostate cancer and lower levels of 3a-diolG, a hormone synthesized in the prostate. The study also found a marginally significant association between the presence of the A49T variant and decreased risk of balding. The findings suggest that the A49T variant may play a role in both prostate cancer risk and androgenetic alopecia.

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