Role of Genetics and Sex Steroid Hormones in Male Androgenetic Alopecia and Female Pattern Hair Loss: An Update

    March 2011 in “ Australasian Journal of Dermatology ”
    Leona Yip, Nick Rufaut, Rod Sinclair
    Studysummary This review explores the current understanding of genetic and hormonal influences on male androgenetic alopecia and female pattern hair loss, providing guidance for clinicians but reports no new results.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on onlinelibrary.wiley.com →
    Discuss this study in the Community →

    Research cited in this study 50

    1. Evidence for Two Independent Functional Variants for Androgenetic Alopecia Around the Androgen Receptor Gene Experimental Dermatology · 2010
    2. Quality of Life in Australian Women with Female Pattern Hair Loss The Open Dermatology Journal · 2010
    3. Future Directions: Gene Polymorphism Diagnostics Relevant to Hair 2010
    4. Evaluation of Androgen Receptor Gene as a Candidate Gene in Female Androgenetic Alopecia International Journal of Dermatology · 2009
    5. Gene-Wide Association Study Between the Aromatase Gene (CYP19A1) and Female Pattern Hair Loss British Journal of Dermatology · 2009
    6. Androgen Receptor Copy Number Variation and Androgenetic Alopecia: A Case-Control Study PLOS ONE · 2009
    7. Susceptibility Variants for Male-Pattern Baldness on Chromosome 20p11 Nature Genetics · 2008
    8. Male-Pattern Baldness Susceptibility Locus at 20p11 Nature Genetics · 2008
    9. The Ludwig Pattern of Androgenetic Alopecia Is Due to a Hierarchy of Androgen Sensitivity Within Follicular Units That Leads to Selective Miniaturization and a Reduction in the Number of Terminal Hairs Per Follicular Unit British Journal of Dermatology · 2008
    10. EDA2R Is Associated With Androgenetic Alopecia Journal of Investigative Dermatology · 2008
    11. Genome-Wide Scan and Fine-Mapping Linkage Study of Androgenetic Alopecia Reveals a Locus on Chromosome 3q26 American Journal of Human Genetics · 2008
    12. Premature Senescence of Balding Dermal Papilla Cells In Vitro Is Associated With p16INK4a Expression Journal of Investigative Dermatology · 2007
    13. Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes Journal of Investigative Dermatology · 2007
    14. Men With Kennedy Disease Have a Reduced Risk of Androgenetic Alopecia British Journal of Dermatology · 2007
    15. Baldness And The Androgen Receptor: The AR Polyglycine Repeat Polymorphism Does Not Confer Susceptibility To Androgenetic Alopecia Human Genetics · 2007
    16. 5α-Reductase Type 2 Gene Variant Associations with Prostate Cancer Risk, Circulating Hormone Levels, and Androgenetic Alopecia International Journal of Cancer · 2006
    17. The Hair Follicle as an Estrogen Target and Source Endocrine Reviews · 2006
    18. Antiandrogen Therapy for Androgenetic Alopecia Expert Review of Dermatology · 2006
    19. Therapeutic Strategies for Treating Hair Loss Drug Discovery Today: Therapeutic Strategies · 2006
    20. Decreased Androgen Receptor Gene Methylation in Premature Pubarche: A Novel Pathogenetic Mechanism? ˜The œJournal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 2006
    21. Effect of 5α-Dihydrotestosterone and Testosterone on Apoptosis in Human Dermal Papilla Cells Skin Pharmacology and Physiology · 2006
    22. Biology of Estrogens in Skin: Implications for Skin Aging Experimental Dermatology · 2005
    23. Role of Androgen in Mesenchymal Epithelial Interactions in Human Hair Follicle Journal of Investigative Dermatology Symposium Proceedings · 2005
    24. Prevalence of Male and Female Pattern Hair Loss in Maryborough Journal of Investigative Dermatology Symposium Proceedings · 2005
    25. Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia American Journal of Human Genetics · 2005
    26. The E211 G>A Androgen Receptor Polymorphism Is Associated With a Decreased Risk of Metastatic Prostate Cancer and Androgenetic Alopecia Cancer Epidemiology, Biomarkers & Prevention · 2005
    27. Evaluation and Treatment of Male and Female Pattern Hair Loss Journal of The American Academy of Dermatology · 2004
    28. Chronic Telogen Effluvium or Early Androgenetic Alopecia? International Journal of Dermatology · 2004
    29. Genetic Basis of Male Pattern Baldness Journal of Investigative Dermatology · 2003
    30. Plasticity and Cytokinetic Dynamics of the Hair Follicle Mesenchyme: Implications for Hair Growth Control Journal of Investigative Dermatology · 2003
    31. Androgens and Alopecia Molecular and Cellular Endocrinology · 2002
    32. The Hairless Gene in Androgenetic Alopecia: Results of a Systematic Mutation Screening and a Family-Based Association Approach British Journal of Dermatology · 2002
    33. Female Pattern Hair Loss Journal of The American Academy of Dermatology · 2001
    34. Possible Mechanisms of Miniaturization During Androgenetic Alopecia or Pattern Hair Loss Journal of The American Academy of Dermatology · 2001
    35. Polymorphism of the Androgen Receptor Gene Is Associated with Male Pattern Baldness Journal of Investigative Dermatology · 2001
    36. The Genetics of Androgenetic Alopecia Clinics in Dermatology · 2001
    37. Incidence of Female Androgenetic Alopecia (Female Pattern Alopecia) Dermatologic Surgery · 2001
    38. Female Androgenetic Alopecia: A Separate Entity Dermatologic Surgery · 2000
    39. Hair Disorders Primary Care · 2000
    40. Androgenetic Alopecia in Heterozygous Carriers of a Mutation in the Human Hairless Gene Journal of The American Academy of Dermatology · 2000
    41. Measuring Reversal of Hair Miniaturization in Androgenetic Alopecia by Follicular Counts in Horizontal Sections of Serial Scalp Biopsies: Results of Finasteride 1mg Treatment of Men and Postmenopausal Women Journal of Investigative Dermatology Symposium Proceedings · 1999
    42. Diffuse Female Hair Loss: Are Androgens Necessary? British Journal of Dermatology · 1999
    43. Androgen Receptor Polymorphisms (CAG Repeat Lengths) in Androgenetic Alopecia, Hirsutism, and Acne Journal of Cutaneous Medicine and Surgery · 1998
    44. Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia Journal of Investigative Dermatology · 1997
    45. An Estrogen Receptor Pathway Regulates the Telogen-Anagen Hair Follicle Transition and Influences Epidermal Cell Proliferation Proceedings of the National Academy of Sciences of the United States of America · 1996
    46. Androgens and Human Hair Growth Clinical endocrinology · 1994
    47. Patterned Androgenic Alopecia in Women Journal of The American Academy of Dermatology · 1988
    48. The Inheritance Of Common Baldness: To Be Or Not To Be? Journal of the American Academy of Dermatology · 1984
    49. Classification of the Types of Androgenetic Alopecia (Common Baldness) Occurring in the Female Sex British Journal of Dermatology · 1977
    50. The Metabolism of Dehydroepiandrosterone by Human Scalp Hair Follicles The Journal of Clinical Endocrinology & Metabolism · 1973

    Related research 6

    1. Poor Perifollicular Vascularization Is Associated With Nutrient Insufficiency and a Quiescent Metabolic Phenotype in Intermediate Hair Follicles From Patients With Female Pattern Hair Loss Journal of Investigative Dermatology · 2021
    2. The Role of Vitamins and Minerals in Hair Loss: A Review Dermatology and Therapy · 2018
    3. Assessing Significant (>30%) Alopecia as a Possible Biomarker for Stress in Captive Rhesus Monkeys (Macaca Mulatta) American Journal of Primatology · 2016
    4. Role of Genetics and Sex Steroid Hormones in Male Androgenetic Alopecia and Female Pattern Hair Loss: An Update Australasian Journal of Dermatology · 2011
    5. Association Between Smoking and Hair Loss: Another Opportunity for Health Education Against Smoking? Dermatology · 2003
    6. What Controls Hair Follicle Cycling? Experimental dermatology · 1999