Gene-Wide Association Study Between the Aromatase Gene (CYP19A1) and Female Pattern Hair Loss

April 2009 in “ British Journal of Dermatology ”

L. Yip, Sophie Zaloumis, D. Irwin, Gianluca Severi, John L. Hopper, Graham G. Giles, Stephen B. Harrap, Robert Sinclair, John Ellis

aromatase gene CYP19A1 female pattern hair loss FPHL genetic variation allele rs4646 C aromatase female pattern baldness

TLDR Aromatase gene variation may increase female hair loss risk.

This 13-year-old study investigated the association between genetic variation in the aromatase gene (CYP19A1) and female pattern hair loss (FPHL). The study found that a common allele (rs4646 C) in the gene might be associated with predisposition to FPHL. The study involved 484 Caucasian women with grades 3-5 FPHL and 471 Caucasian women with no evidence of hair loss. The study suggests that CYP19A1 genetic variation might influence the risk of developing FPHL.

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