Gene-Wide Association Study Between the Aromatase Gene (CYP19A1) and Female Pattern Hair Loss

    April 2009 in “ British Journal of Dermatology ”
    L. Yip, Sophie Zaloumis, D. Irwin, Gianluca Severi, John L. Hopper, Graham G. Giles, Stephen B. Harrap, Robert Sinclair, John Ellis
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    TLDR Aromatase gene variation may increase female hair loss risk.
    This 13-year-old study investigated the association between genetic variation in the aromatase gene (CYP19A1) and female pattern hair loss (FPHL). The study found that a common allele (rs4646 C) in the gene might be associated with predisposition to FPHL. The study involved 484 Caucasian women with grades 3-5 FPHL and 471 Caucasian women with no evidence of hair loss. The study suggests that CYP19A1 genetic variation might influence the risk of developing FPHL.
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