Association Analysis of Estrogen Receptor Beta Gene (ESR2) Polymorphisms with Female Pattern Hair Loss

This study examined the association between estrogen receptor beta gene (ESR2) polymorphisms and female pattern hair loss (FPHL) using a case-control sample of 484 cases and 471 controls. The results suggest that variation in ESR2 may be associated with FPHL, with the lowest P-values observed for rs10137185, rs17101774, and rs2022748. The study supports the conclusion that estrogen may influence FPHL risk via genetic variation in the estrogen pathway. The findings provide an impetus for further investigating the role of estrogens and examining other genes within the sex steroid pathway in FPHL.