HSD3B1 Gene Polymorphism and Female Pattern Hair Loss in Women with Polycystic Ovary Syndrome

August 2019 in “ Journal of the Formosan Medical Association ”

Yi-An Tu, Sung-Jan Lin, Pei-Lung Chen, Chiahung Chou, Chu-Chun Huang, Hong Nerng Ho, Mei Chen

HSD3B1 gene polymorphism female pattern hair loss polycystic ovary syndrome sex hormone binding globulin high density lipoprotein cholesterol triglyceride levels hypertension FPHL PCOS SHBG HDL cholesterol

TLDR HSD3B1 gene variant and being overweight linked to hair loss in women with polycystic ovary syndrome.

The study found that the HSD3B1 1245C allele and being overweight were positively correlated with the presence of female pattern hair loss (FPHL) in women with polycystic ovary syndrome (PCOS). The study also found that the presence of FPHL in women with PCOS was significantly associated with an increased body mass index, decreased sex hormone binding globulin and high density lipoprotein cholesterol levels, elevated triglyceride levels, and increased prevalence of hypertension. The study suggests that the genetic variant of HSD3B1 may contribute to the development of FPHL in overweight women with PCOS. However, further studies with larger sample sizes are needed to confirm these findings.

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