Higher Levels of Steroidogenic Acute Regulatory Protein and Type I 3β-Hydroxysteroid Dehydrogenase in the Scalp of Men with Androgenetic Alopecia

October 2006 in “ Journal of Investigative Dermatology ”

WenChieh Chen, Shaw Jenq Tsai, Chen-Yu Liao, Ren-Yeu Tsai, Yi-Ju Chen, Bi-Jen Pan, Chiu-Ling Hung, Christos C. Zouboulis

androgenetic alopecia steroidogenic acute regulatory protein type I 3β-hydroxysteroid dehydrogenase androgens de novo androgenesis AGA StAR 3β-HSD

TLDR Men with baldness have higher levels of specific proteins, suggesting local hormone production may play a role in hair loss.

Men with androgenetic alopecia (AGA) have higher levels of steroidogenic acute regulatory protein (StAR) and type I 3β-hydroxysteroid dehydrogenase (3β-HSD) in their bald scalp compared to hairy scalp. This suggests that locally aberrant production of androgens may play a significant role in the development of AGA. However, further studies are needed to determine the role of de novo androgenesis in the pathogenesis of AGA.

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Higher Levels of Steroidogenic Acute Regulatory Protein and Type I 3β-Hydroxysteroid Dehydrogenase in the Scalp of Men with Androgenetic Alopecia

Research cited in this study

research The Distribution of Estrogen Receptor Beta Is Distinct to That of Estrogen Receptor Alpha and the Androgen Receptor in Human Skin and the Pilosebaceous Unit

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