Investigation of the Male Pattern Baldness Major Genetic Susceptibility Loci AR/EDA2R and 20p11 in Female Pattern Hair Loss

February 2012 in “ British Journal of Dermatology ”

Silke Redler, Felix F. Brockschmidt, Rachid Tazi-Ahnini, Dmitriy Drichel, M.P. Birch, K. Dobson, Kathrin A. Giehl, Stefan Herms, Melanie Refke, Nadine Kluck, Rudolf Kruse, G. Lutz, Helmut H. Wolff, Michael Böhm, Thomas Becker, Markus M. Nöthen, Andrew G. Messenger, Robert E. Betz

female pattern hair loss FPHL AR/EDA2R 20p11 genetic susceptibility loci early-onset FPHL male pattern baldness susceptibility alleles

Studysummary This study suggests that the AR/EDA2R locus may contribute to early-onset female pattern hair loss, but no association was found with the 20p11 locus.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

This study investigated the role of two major genetic susceptibility loci, AR/EDA2R and 20p11, in female pattern hair loss (FPHL). The study involved 145 UK and 85 German patients with FPHL, 179 UK supercontrols, and 150 German blood donors. The results showed that the AR/EDA2R locus confers susceptibility to early-onset FPHL, but the 20p11 locus is not implicated in the aetiology of FPHL. The study suggests that FPHL and male pattern baldness share common susceptibility alleles.

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research Evidence for Two Independent Functional Variants for Androgenetic Alopecia Around the Androgen Receptor Gene

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This abstract contains only supplementary material information and reports no new research findings.

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research Prevalence of Male and Female Pattern Hair Loss in Maryborough

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research Hair Density, Hair Diameter, and the Prevalence of Female Pattern Hair Loss

234 citations , February 2001 in “British Journal of Dermatology”

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research Role of Androgens in Female-Pattern Androgenetic Alopecia, Either Alone or Associated with Other Symptoms of Hyperandrogenism

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research Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia

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research The Inheritance Of Common Baldness: To Be Or Not To Be?

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