Evidence for Two Independent Functional Variants for Androgenetic Alopecia Around the Androgen Receptor Gene

September 2010 in “ Experimental Dermatology ”

J Cobb, Sophie Zaloumis, Katrina J Scurrah, Stephen B. Harrap, Justine A. Ellis

androgen receptor AR male pattern baldness AGA androgenetic alopecia Chr20 region ChrX region

TLDR Two gene areas linked to male pattern baldness found, more research needed.

This study investigated the gene encoding the androgen receptor (AR) and its association with male pattern baldness (AGA). Results showed evidence of two independent loci associated with AGA - one upstream of AR that had been previously described, and a novel downstream region. Further investigation into these non-coding regions is needed to identify functional variants that contribute to AGA, as well as further research into the Chr20 region which appears to have a lesser influence on AGA than the ChrX region.

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Research cited in this study

7 / 7 results

research Male-Pattern Baldness Susceptibility Locus at 20p11

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research EDA2R Is Associated With Androgenetic Alopecia

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research Baldness And The Androgen Receptor: The AR Polyglycine Repeat Polymorphism Does Not Confer Susceptibility To Androgenetic Alopecia

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research Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia

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The E211 G>A Androgen Receptor Polymorphism Is Associated With a Decreased Risk of Metastatic Prostate Cancer and Androgenetic Alopecia

research The E211 G>A Androgen Receptor Polymorphism Is Associated With a Decreased Risk of Metastatic Prostate Cancer and Androgenetic Alopecia

76 citations , April 2005 in “Cancer Epidemiology, Biomarkers & Prevention”

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research Polymorphism of the Androgen Receptor Gene Is Associated with Male Pattern Baldness

299 citations , March 2001 in “Journal of Investigative Dermatology”

Male pattern baldness is linked to specific genetic variations in the androgen receptor gene.

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