Androgen Receptor Expression in Male Pattern Baldness Patients

January 2012 in “ Chinese Journal of Aesthetic Medicine ”

Bin Ji

androgen receptor AR androgenetic alopecia AGA hair follicle male pattern baldness scalp hair follicle bulge infundibulum epidermis sebaceous glands male pattern hair loss

TLDR Increased androgen receptor expression in certain hair follicle areas may cause male pattern baldness.

The study investigated androgen receptor (AR) expression in hair follicles from different scalp areas of 10 male androgenetic alopecia (AGA) patients and 3 individuals with normal scalps. It found that AR expression was significantly stronger in the hair follicle bulge and infundibulum of hair loss and transitional areas compared to the occipital area and normal controls. However, AR expression in the epidermis showed no significant difference across scalp areas but differed from normal controls. In sebaceous glands, AR expression did not significantly differ among groups. The findings suggested that increased AR expression in specific hair follicle regions might be a key factor in male pattern hair loss.

View this study on en.cnki.com.cn →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 3 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community My Theory Regarding a Cause and Cure for Androgenetic Alopecia

in Treatment 98 upvotes 4 years ago

Hair loss theory suggests imbalance between Vitamin D Receptor (VDR) and Androgen Receptor (AR) activation. Proposed treatment includes upregulating VDR, downregulating AR, and improving mitochondrial health.

community GT20029 China Phase II Trial For AGA Reached Primary Endpoint

in Research/Science 136 upvotes 7 months ago

The GT20029 tincture, a topical androgen receptor degrader, showed significant hair growth and good safety in a China Phase II trial for male androgenetic alopecia (AGA), with the 1% dose twice weekly identified as optimal. The company plans to initiate Phase III trials in China and Phase II in the U.S., and the treatment also shows promise for acne.

community SCUBE3 and GT20029 could be the closet thing to a cure: Hair Follicle Regeneration and Protection Against DHT

in Research/Science 13 upvotes 1 year ago

SCUBE3 and GT20029 are potential treatments for hair loss, with SCUBE3 stimulating hair growth and GT20029 protecting against DHT. A combined approach using SCUBE3, finasteride or dutasteride, and later GT20029 could provide a comprehensive treatment for androgenetic alopecia.

community Reminder that Kintors Pyrilutamide results will be out this month

in Treatment 178 upvotes 3 years ago

Kintor's Pyrilutamide results for hair loss treatment will be released soon. The treatment may replace current treatments like finasteride and minoxidil without systemic side effects.

community Finasteride doesn't work for me in 2 years and my bloodtest result just came in.

in Progress Pictures 88 upvotes 1 year ago

A user has been treating hair loss with finasteride for two years without success and is experiencing an itchy scalp with seborrhea. Despite low DHT levels, they are still losing hair, suggesting that DHT might not be the main cause of their hair loss, and they are considering other treatments or causes.

Related Research

11 / 11 results

research Female Pattern Hair Loss

January 2023 in “Skinmed”

The document suggests managing female pattern hair loss by checking and correcting B12, folate, and thyroid levels, and considering an androgen profile if there are signs of excess androgen.

research Distribution of Polyamines May Be Altered in Different Scalp Regions of Patients with Hair Loss

3 citations, July 2019 in “Experimental Dermatology”

Hair loss patients may have different polyamine levels in various scalp areas.

research Microbiome in the Hair Follicle of Androgenetic Alopecia Patients

26 citations, May 2019 in “PLOS ONE”

Hair loss patients have different microbes in hair follicles, possibly affecting hair loss.

research Effects of SM-215 on Hair Growth by Hair Follicle Stimulation

2 citations, October 2015 in “Indian journal of science and technology”

SM-215 promotes hair growth by improving the environment around hair follicles.

research The Observation of Androgen Receptor Expression in Androgenetic Alopecia Patients

January 2014 in “Medical Innovation of China”

research An Overview of Female Pattern Hair Loss

2 citations, June 2011 in “Expert Review of Dermatology”

Female pattern hair loss involves thinning hair on crown and frontal scalp, diagnosed by hair ratio, and treated with minoxidil, antiandrogens, or hair transplantation.

research Intermediate Hair Follicles: A New, More Clinically Relevant Model for Hair Growth Investigations

30 citations, May 2010 in “British Journal of Dermatology”

Intermediate hair follicles are a better model for studying hair growth and testing hair loss treatments.

research Hair Follicular Expression of Integrin Alpha-6 Subunit and p63 in Hair Loss

January 2008 in “Journal of Clinical Dermatology”

Integrin alpha-6 and p63 proteins may play a role in hair loss and are important for hair growth and maintenance.

research Expression of Beta-Catenin, p63, and CD34 in Hair Follicles During the Course of Androgenetic Alopecia

4 citations, August 2005 in “Archives of Dermatological Research”

Higher p63 and CD34 levels found in specific scalp areas may affect hair loss progression.

research Male Androgenetic Alopecia

17 citations, December 2004 in “The Journal of Men's Health & Gender”

Male pattern baldness involves hormone-related hair thinning, shorter hair, and inflammation.

research Drugs Affecting Hair Growth

January 1990

Different hair growth phases affect how follicles respond to X-rays, and hormones like testosterone and dihydrotestosterone play a key role in baldness; transplanted hair can grow on bald scalp areas.