The Feasibility of Quantitative Analysis of Androgen Metabolism Using Single Dermal Papillae from Human Hair Follicles

April 2001 in “ Experimental Dermatology ”

S Niiyama, Rudolf Happle, R. Hoffmann

androgen metabolism dermal papillae human hair follicles androgenetic alopecia 5α‐reductase type 2 5α‐reductase HPLC-radiomatic flow scintillation occipital scalp AGA 5aR DP

TLDR Using single dermal papillae is unreliable for analyzing androgen metabolism in hair follicles.

The study explored the feasibility of quantitatively analyzing androgen metabolism by using single dermal papillae (DP) from human hair follicles, particularly in the context of androgenetic alopecia (AGA). AGA is characterized by the miniaturization of androgen-sensitive hair follicles, with increased 5α-reductase (5aR) activity being a key factor. The researchers employed a novel method using freshly isolated DP and a highly sensitive HPLC-radiomatic flow scintillation system to measure 5aR activity. They found that DP from the occipital scalp exhibited significant 5aR activity, although there was considerable variability in enzyme activity among individual DP. The study concluded that using only one or two DP is not currently a reliable method for analyzing 5aR activity ex vivo due to this variability.

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Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

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Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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