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    Glossary Dermal Papillae

    small skin projections crucial for hair growth and nutrient supply

    Dermal papillae are small, nipple-like extensions of the dermis (the inner layer of the skin) that project into the epidermis (the outer layer of the skin). In the context of hair, they are located at the base of hair follicles and play a crucial role in hair growth by supplying nutrients and signaling molecules to the hair matrix cells, which are responsible for producing hair.

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    Research 10 of 1000+

    1. Sox2-positive dermal papilla cells specify hair follicle type in mammalian epidermis Development · 2009 · 338 citations
    2. β-catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair Developmental Cell · 2010 · 314 citations
    3. Differences in Hair Follicle Dermal Papilla Volume are Due to Extracellular Matrix Volume and Cell Number: Implications for the Control of Hair Follicle Size and Androgen Responses Journal of Investigative Dermatology · 1999 · 231 citations
    4. Balding hair follicle dermal papilla cells contain higher levels of androgen receptors than those from non-balding scalp Journal of Endocrinology · 1998 · 227 citations
    5. Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla Journal of Investigative Dermatology · 2003 · 208 citations
    6. The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle Cold Spring Harbor Perspectives in Medicine · 2014 · 149 citations
    7. Shh maintains dermal papilla identity and hair morphogenesis via a Noggin–Shh regulatory loop Genes & Development · 2012 · 138 citations
    8. Extracellular vesicles derived from MSCs activates dermal papilla cell in vitro and promotes hair follicle conversion from telogen to anagen in mice Scientific Reports · 2017 · 113 citations
    9. Hair follicle stem cell differentiation is inhibited through cross‐talk between Wnt/β‐catenin and androgen signalling in dermal papilla cells from patients with androgenetic alopecia British Journal of Dermatology · 2012 · 95 citations
    10. Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells PLOS ONE · 2012 · 85 citations
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    Community 10 of 638

    1. HairClone (UK) finally begins offering its Dermal Papilla Cell Hair Multiplication procedure to humans. In Guatemala. Reddit · 24 Feb 2026
    2. New Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness - Paper entitled "Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type" published journal Developmental Cell Reddit · 24 Dec 2014
    3. [Nov 2019] The peptide AC 2 isolated from Bacillus-treated Trapa japonica fruit extract rescues DHT (dihydrotestosterone)-treated human dermal papilla cells and mediates mTORC1 signaling for autophagy and apoptosis suppression Reddit · 4 Dec 2019
    4. Hair follicle dermal papilla exosomes Reddit · 7 Jul 2025
    5. Dr Kyle Gillett on topical Dutasteride Reddit · 21 Dec 2022
    6. DIY Dutasteride Mesotherapy....THE ULTIMATE EXPERIMENT WITH RESULTS! Reddit · 2 Apr 2021
    7. Everything you ever wanted to know about Pelage Pharma's PP405: how it works and what to expect Reddit · 18 Jun 2026
    8. New Hair Loss Cure: AMP-303 Is Back. It’s what PP405 should have been. Reddit · 2 Apr 2026
    9. Oxytocin, empathy, hair, and cinnamon Community · 12 Aug 2024
    10. How soon is hair clone? Next five years?! Reddit · 24 Jun 2024
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    Learn 9 of 10

    1. Hair Multiplication extract, clone, and reinsert your own hair cells
    2. SCUBE3 Signalling protein made in the hair follicle
    3. KY19382 Experimental compound that activates hair-growth signals, tested only in animals
    4. Exosomes Tiny cell-derived particles offered by clinics as an injectable treatment
    5. Redensyl Cosmetic ingredient blend sold for thinning hair
    6. GHK-Cu Copper peptide used in skin and hair cosmetics
    7. Minoxidil Vasodilator used on the scalp and, at low doses, as a tablet
    8. Valproic acid Anti-seizure and mood-stabilising drug
    9. Stem Cell Factor
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