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    Glossary Dermal Papillae

    small skin projections crucial for hair growth and nutrient supply

    Dermal papillae are small, nipple-like extensions of the dermis (the inner layer of the skin) that project into the epidermis (the outer layer of the skin). In the context of hair, they are located at the base of hair follicles and play a crucial role in hair growth by supplying nutrients and signaling molecules to the hair matrix cells, which are responsible for producing hair.

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    1. Sox2-positive dermal papilla cells specify hair follicle type in mammalian epidermis Development · 2009 · 338 citations
    2. β-catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair Developmental Cell · 2010 · 314 citations
    3. Differences in Hair Follicle Dermal Papilla Volume are Due to Extracellular Matrix Volume and Cell Number: Implications for the Control of Hair Follicle Size and Androgen Responses Journal of Investigative Dermatology · 1999 · 231 citations
    4. Balding hair follicle dermal papilla cells contain higher levels of androgen receptors than those from non-balding scalp Journal of Endocrinology · 1998 · 227 citations
    5. Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla Journal of Investigative Dermatology · 2003 · 208 citations
    6. The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle Cold Spring Harbor Perspectives in Medicine · 2014 · 149 citations
    7. Shh maintains dermal papilla identity and hair morphogenesis via a Noggin–Shh regulatory loop Genes & Development · 2012 · 138 citations
    8. Extracellular vesicles derived from MSCs activates dermal papilla cell in vitro and promotes hair follicle conversion from telogen to anagen in mice Scientific Reports · 2017 · 113 citations
    9. Hair follicle stem cell differentiation is inhibited through cross‐talk between Wnt/β‐catenin and androgen signalling in dermal papilla cells from patients with androgenetic alopecia British Journal of Dermatology · 2012 · 95 citations
    10. Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells PLOS ONE · 2012 · 85 citations
    11. Transcriptome Sequencing Reveals Differences between Primary and Secondary Hair Follicle-derived Dermal Papilla Cells of the Cashmere Goat (Capra hircus) PLoS ONE · 2013 · 81 citations
    12. Scalable production of controllable dermal papilla spheroids on PVA surfaces and the effects of spheroid size on hair follicle regeneration Biomaterials · 2012 · 78 citations
    13. Exosomal Micro RNAs Derived from Dermal Papilla Cells Mediate Hair Follicle Stem Cell Proliferation and Differentiation International journal of biological sciences · 2019 · 71 citations
    14. Clonal Growth of Dermal Papilla Cells in Hydrogels Reveals Intrinsic Differences between Sox2-Positive and -Negative Cells In Vitro and In Vivo Journal of Investigative Dermatology · 2011 · 68 citations
    15. The Modulation of Aromatase and Estrogen Receptor Alpha in Cultured Human Dermal Papilla Cells by Dexamethasone: A Novel Mechanism for Selective Action of Estrogen via Estrogen Receptor Beta? Journal of Investigative Dermatology · 2006 · 65 citations
    16. Steroid Sulfatase in the Human Hair Follicle Concentrates in the Dermal Papilla Journal of Investigative Dermatology · 2001 · 61 citations
    17. Methods for the isolation and 3D culture of dermal papilla cells from human hair follicles Experimental Dermatology · 2017 · 55 citations
    18. Dissociated Human Dermal Papilla Cells Induce Hair Follicle Neogenesis in Grafted Dermal–Epidermal Composites Journal of Investigative Dermatology · 2013 · 51 citations
    19. Sprouty/FGF signaling regulates the proximal–distal feather morphology and the size of dermal papillae Developmental Biology · 2012 · 50 citations
    20. The chemotactic effect of a dermal papilla cell-derived factor on outer root sheath cells Journal of Dermatological Science · 2001 · 47 citations
    21. Controllable Production of Transplantable Adult Human High-Passage Dermal Papilla Spheroids Using 3D Matrigel Culture Tissue engineering. Part A · 2014 · 46 citations
    22. The enhancement of dermal papilla cell aggregation by extracellular matrix proteins through effects on cell–substratum adhesivity and cell motility Biomaterials · 2009 · 44 citations
    23. Hair Germ Model In Vitro via Human Postnatal Keratinocyte-Dermal Papilla Interactions: Impact of Hyaluronic Acid Stem cells international · 2017 · 42 citations
    24. De Novo Production of Dermal Papilla Cells during the Anagen Phase of the Hair Cycle Journal of Investigative Dermatology · 2010 · 41 citations
    25. Differences in Expression of Specific Biomarkers Distinguish Human Beard from Scalp Dermal Papilla Cells Journal of Investigative Dermatology · 2006 · 41 citations
    26. 5α-Reductase activity in the human hair follicle concentrates in the dermal papilla Archives of Dermatological Research · 1998 · 41 citations
    27. Wnt activator CHIR99021-stimulated human dermal papilla spheroids contribute to hair follicle formation and production of reconstituted follicle-enriched human skin Biochemical and Biophysical Research Communications · 2019 · 40 citations
    28. Extracellular Vesicles from Activated Dermal Fibroblasts Stimulate Hair Follicle Growth Through Dermal Papilla-Secreted Norrin Stem cells · 2019 · 37 citations
    29. Co‐culture of Human Hair Follicles and Dermal Papillae in a Collagen Matrix The Journal of Dermatology · 1990 · 36 citations
    30. Stress-induced premature senescence of dermal papilla cells compromises hair follicle epithelial-mesenchymal interaction Journal of Dermatological Science · 2017 · 35 citations