Search

for
Search:

Glossary Dermal Papilla-Like Cells

lab-grown cells mimicking natural dermal papilla cells for hair growth

Dermal Papilla-Like Cells (DPLCs) are lab-grown cells that mimic the properties and functions of natural dermal papilla cells, which are found at the base of hair follicles and play a crucial role in hair growth and regeneration. These cells are often used in research and therapeutic applications to study hair loss conditions like alopecia and to develop potential treatments for promoting hair regrowth.

Related Terms

Research

5 / 1000+ results

research Trajectory of hiPSCs derived neural progenitor cells differentiation into dermal papilla-like cells and their characteristics

August 2023 in “Scientific reports”

In this study, researchers differentiated human induced pluripotent stem cells into dermal papilla-like cells and observed gene expression dynamics during five stages of dermal differentiation, demonstrating the potential of these cells to interact with epidermal cells in functional assays.

research Hair multiplication with dermal papilla like tissue containing human dermal papilla cells

June 2014 in “Biotechnology and Bioprocess Engineering”

This study demonstrated that injecting reconstructed dermal papilla-like tissues in mice led to new hair growth, suggesting potential future applications in hair transplantation and baldness treatment.

research Dermal Papilla Cells Improve the Wound Healing Process and Generate Hair Bud-Like Structures in Grafted Skin Substitutes Using Hair Follicle Stem Cells

68 citations , August 2014 in “Stem Cells Translational Medicine”

This study found that composite skin constructs containing dermal papilla cells promoted better skin healing and hair regeneration in nude mice, highlighting their role in tissue-engineered skin for severe injuries.

research Optimization of the reconstruction of dermal papilla like tissues employing umbilical cord mesenchymal stem cells

6 citations , February 2010 in “Biotechnology and bioprocess engineering”

This study investigated optimizing the differentiation process of UC-MSCs into dermal papilla-like tissues for potential hair follicle therapy and highlighted the potential to reduce associated costs by evaluating cell density and growth factors.

research Androgen Induction of Follicular Epithelial Cell Growth Is Mediated via Insulin-like Growth Factor-I from Dermal Papilla Cells

173 citations , July 1995 in “Biochemical and biophysical research communications”

This study suggests that IGF-I may mediate androgen-induced hair growth in outer root sheath cells cocultured with beard dermal papilla cells.

View more "dermal papilla-like cells" in research →

Community Join

5 / 1000+ results

community HairClone (UK) finally begins offering its Dermal Papilla Cell Hair Multiplication procedure to humans. In Guatemala.

149 upvotes 7 months ago

HairClone is offering a Dermal Papilla Cell Hair Multiplication procedure in Guatemala, raising questions about its effectiveness and regulatory reasons for the location. Users express skepticism and curiosity about the treatment's success and potential costs.

community New Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness - Paper entitled "Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type" published journal Developmental Cell

13 upvotes 11 years ago

A new treatment using dermal sheath cup cells may regrow hair and could require repeat treatments every 8 years. Users discuss ongoing trials and plan to use finasteride and minoxidil until the treatment is available.

community [Nov 2019] The peptide AC 2 isolated from Bacillus-treated Trapa japonica fruit extract rescues DHT (dihydrotestosterone)-treated human dermal papilla cells and mediates mTORC1 signaling for autophagy and apoptosis suppression

23 upvotes 6 years ago

A peptide from Japanese water chestnut fruit may help with hair loss by suppressing DHT's effect on hair follicle cell death, potentially serving as a finasteride alternative. The treatment's effectiveness and safety in humans remain uncertain.

community New Hair Loss Cure: AMP-303 Is Back. It’s what PP405 should have been.

7 upvotes 5 months ago

AMP-303 and AMP-601 are new hair loss treatments targeting dermal papilla cells, with AMP-303 showing early efficacy in transitioning vellus hairs to terminal hairs after one injection. Further clinical trials are planned, and these treatments are seen as promising due to their biologic approach and less frequent application compared to daily treatments.

community NMN Promotes Cell Proliferation and Hair Growth by Reducing Oxidative Stress

14 upvotes 2 years ago

NMN shows promise in promoting hair growth by reducing oxidative stress and weakening androgens. It may be a beneficial addition to hair loss treatments like Minoxidil and Finasteride.

View more "dermal papilla-like cells" in community →

Learn

4 / 800 results

learn SCUBE3

Signalling protein made in the hair follicle

How does SCUBE3 work on hair follicles compared to treatments like minoxidil or finasteride? Laboratory research in mice reports that SCUBE3, a protein released by dermal papilla cells, signals dormant follicles to grow through the TGF-β pathway downstream of Hedgehog; minoxidil and finasteride instead work on blood flow to the follicle and on DHT, and unlike SCUBE3 they have decades of human trial data behind them. SCUBE3 has not been tested in human clinical trials and is not available as a medicine.

learn Stem Cell Factor

learn Exosomes

Tiny cell-derived particles offered by clinics as an injectable treatment

learn KY19382

Experimental compound that activates hair-growth signals, tested only in animals

View more "dermal papilla-like cells" in learn →

Clinics

3 / 15 results

Experts

— no results

Try a deeper search in experts →