Trajectory of Human Induced Pluripotent Stem Cells Derived Neural Progenitor Cells Differentiation into Dermal Papilla-Like Cells and Their Characteristics

    August 2023 in “ Scientific reports ”
    Andrei Riabinin, Ekaterina P. Kalabusheva, А. М. Хрусталева, Mikhail Akulinin, Alexander Tyakht, E. O. Osidak, E. S. Chermnykh, A. V. Vasiliev, E. A. Vorotelyak
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    TLDR Human stem cells were turned into cells similar to those that help grow hair and showed potential for hair follicle formation.
    This study explored the differentiation of human induced pluripotent stem cells (hiPSCs) into dermal papilla-like cells (DP-like cells), which are crucial for hair generation. The researchers directed hiPSCs to first become neural progenitor cells (NPCs) and then differentiated them into DP-like cells. They monitored the gene expression changes across five stages of dermal differentiation using bulk RNA-seq data. Additionally, they conducted functional assays, including organoid formation in collagen gels and hanging drop cultures, as well as tubulogenesis assays, to assess the ability of the generated dermal cell lines to interact with epidermal cells. The results indicated that the hiPSC-derived DP-like cells exhibited the potential for epithelial-mesenchymal interaction, which is essential for hair follicle formation and function.
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