Induction of Hair Follicle Dermal Papilla Cell Properties in Human Induced Pluripotent Stem Cell-Derived Multipotent LNGFR(+)THY-1(+) Mesenchymal Cells

    February 2017 in “ Scientific Reports ”
    Ophelia Veraitch, Yo Mabuchi, Yasushi Matsuzaki, Takashi Sasaki, Hiroyuki Okuno, Aki Tsukashima, Masayuki Amagai, Hideyuki Okano, Manabu Ohyama
    Image of study
    TLDR Researchers found a way to create cells from stem cells that act like human cells important for hair growth and could be used for hair regeneration treatments.
    In the 2017 study, researchers developed a method to differentiate human induced pluripotent stem cells (hiPSCs) into mesenchymal cells (iMCs) with characteristics of human dermal papilla (DP) cells, which are essential for hair follicle development and regeneration. They identified a subset of iMCs with LNGFR(+)THY-1(+) expression that, when treated with retinoic acid and DP cell activating culture medium, upregulated DP markers and interacted with human keratinocytes to promote hair follicle-related gene expression and hair shaft-like structure formation in vivo. These induced DP-substituting cells (iDPSCs) also responded to minoxidil sulfate, indicating their potential for use in hair follicle bioengineering and hair disease drug screening. The study involved a total of 56 mice across seven independent experiments, with specific numbers for different cell types: 28 mice for human DP cells, 4 for LNGFR(+)THY-1(+) iMCs, and 24 for iDPSCs. Despite these promising results, the iDPSCs did not consistently form distinct cell aggregates or induce hair structures as effectively as human DP cells, suggesting the need for further refinement of the induction protocol.
    Discuss this study in the Community →

    Research cited in this study

    24 / 24 results

    Related Community Posts Join

    6 / 1000+ results

      community Fats on your Head to Stop Hair Loss?

      in Research/Science  142 upvotes 10 months ago
      The conversation discusses the potential of long-chain unsaturated fatty acids, like oleic and linoleic acid, as an additional treatment for hair loss, which may inhibit the enzyme responsible for converting testosterone to DHT and promote hair growth. Users humorously suggest using oils topically and discuss other hair loss treatments, but the main focus is on the science behind fatty acids and their role in hair health.

      community Please explain this Minoxidil phenomena

      in Minoxidil  56 upvotes 1 year ago
      The post discusses the difference in effects of Minoxidil (Min) on scalp and facial hair. The user questions why Min-induced hair growth on the scalp is temporary, while facial hair growth seems permanent, even after stopping Min. They propose theories, including different Min mechanisms on body and facial hair, the role of DHT, and the possibility of not achieving fully terminal hair. The responses include personal experiences and theories about Min's effects on hair growth.

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  42 upvotes 4 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

      community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

      in Research/Science  743 upvotes 2 years ago
      A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

    Related Research

    6 / 6 results