Direct Reprogramming of Human Fibroblasts Into Hair-Inducing Dermal Papilla Cell-Like Cells by a Single Small Molecule

January 2025 in “ Biochemical Pharmacology ”

Qinglan Zeng, Yihe Ma, Rui Cai, Xinxin Li, Yilin Luo, Binkai Zheng, Gaofeng Wang, Xuejuan Xu, Xusheng Wang, Zhongjie Liu

peficitinib hair-inducing dermal papilla cell-like cells fibroblasts dermal papilla cells Wnt signaling pathway TGF-β signaling pathway hair follicle development

Studysummary In this study, fibroblasts treated with the small molecule peficitinib were reprogrammed into dermal papilla cell-like cells capable of inducing hair growth, offering a new strategy for hair loss treatment.

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