Causes of Hair Loss and Developments in Hair Rejuvenation

    D. H. Rushton, Michael Norris, R. Dover, Nina Busuttil
    From the encyclopedia
    Minoxidil →

    An essential vasodilator with some anti-androgenic effects

    Finasteride →

    Frontline, gold standard treatment for combatting androgenic alopecia

    Cyproterone →

    a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

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    Studysummary This review discusses genetic and nutritional causes of hair loss, highlighting that around 90% of treated men show noticeable hair regrowth with a dual inhibitor, while women's hair loss may improve by correcting iron and l-lysine deficiencies.
    Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
    The 2002 document outlines the psychological effects of hair loss and the treatments available at that time. It states that by age 50, up to 50% of men experience genetic hair loss, with initial treatments like minoxidil being disappointing. However, finasteride and a dual type I and II 5α-reductase inhibitor showed significant improvements, with the latter resulting in hair regrowth in 90% of treated individuals. For women, hair loss before age 50 is primarily nutritional, affecting 30%, with iron and L-lysine deficiencies being key factors. Treatments for women's genetic hair loss included oral estrogen, cyproterone acetate, and spironolactone, with the former two being more effective. The document concludes that while some hair loss can be treated, particularly nutritionally induced loss in women, there remain untreatable conditions that impact quality of life.
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