Pharmacologic Inhibition of JAK-STAT Signaling Promotes Hair Growth

    October 2015 in “ Science Advances ”
    Sivan Harel, Claire A. Higgins, Jane E. Cerise … Angela M. Christiano
    Studysummary This study observed that applying JAK-STAT pathway inhibitors to mouse and human skin led to rapid hair growth by inducing the anagen phase of hair follicles.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on advances.sciencemag.org →
    Discuss this study in the Community →

    Research cited in this study 30

    1. Familial Aggregation of Alopecia Areata Journal of the American Academy of Dermatology · 2016
    2. Reversal of Alopecia Areata Following Treatment With the JAK1/2 Inhibitor Baricitinib EBioMedicine · 2015
    3. Macrophages Contribute to the Cyclic Activation of Adult Hair Follicle Stem Cells PLoS Biology · 2014
    4. Inhibiting Janus Kinases to Treat Alopecia Areata Nature medicine · 2014
    5. Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014
    6. Killing Two Birds with One Stone: Oral Tofacitinib Reverses Alopecia Universalis in a Patient with Plaque Psoriasis Journal of Investigative Dermatology · 2014
    7. Calcineurin/NFATc1 Signaling Links Skin Stem Cell Quiescence to Hormonal Signaling During Pregnancy and Lactation Genes & Development · 2014
    8. Microenvironmental Reprogramming by Three-Dimensional Culture Enables Dermal Papilla Cells to Induce De Novo Human Hair-Follicle Growth Proceedings of the National Academy of Sciences of the United States of America · 2013
    9. Fgf9 From Dermal γδ T Cells Induces Hair Follicle Neogenesis After Wounding Nature Medicine · 2013
    10. Mammalian Target of Rapamycin Complex 1 (mTORC1) May Modulate the Timing of Anagen Entry in Mouse Hair Follicles Experimental dermatology · 2012
    11. Age-Associated Inflammation Inhibits Epidermal Stem Cell Function Genes & development · 2012
    12. Shh Maintains Dermal Papilla Identity and Hair Morphogenesis via a Noggin–Shh Regulatory Loop Genes & Development · 2012
    13. Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation Cell stem cell · 2012
    14. Dihydrotestosterone-Inducible IL-6 Inhibits Elongation of Human Hair Shafts by Suppressing Matrix Cell Proliferation and Promotes Regression of Hair Follicles in Mice Journal of Investigative Dermatology · 2011
    15. Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling Cell · 2011
    16. Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration Cell · 2011
    17. Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells Cell stem cell · 2011
    18. Self-Organizing and Stochastic Behaviors During the Regeneration of Hair Stem Cells Science · 2011
    19. Ex Vivo Organ Culture of Human Hair Follicles: A Model Epithelial–Neuroectodermal–Mesenchymal Interaction System Methods in molecular biology · 2010
    20. Control of Hair Follicle Cell Fate by Underlying Mesenchyme Through a CSL–Wnt5a–FoxN1 Regulatory Axis Genes & development · 2010
    21. Sox2-Positive Dermal Papilla Cells Specify Hair Follicle Type in Mammalian Epidermis Development · 2009
    22. Isolation and Short-Term Culture of Primary Keratinocytes, Hair Follicle Populations, and Dermal Cells from Newborn Mice and Keratinocytes from Adult Mice for In Vitro Analysis and Grafting to Immunodeficient Mice Nature Protocols · 2008
    23. The Hair Cycle Journal of Cell Science · 2006
    24. Modulation of Hair Growth with Small Molecule Agonists of the Hedgehog Signaling Pathway Journal of Investigative Dermatology · 2005
    25. Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle PLoS biology · 2005
    26. Organogenesis From Dissociated Cells: Generation of Mature Cycling Hair Follicles From Skin-Derived Cells Journal of Investigative Dermatology · 2005
    27. Regulation of PDGF and PDGF Receptor in Cultured Dermal Papilla Cells and Follicular Keratinocytes of the Human Hair Follicle Experimental Dermatology · 2003
    28. Two Distinct Signaling Pathways in Hair Cycle Induction: Stat3-Dependent and Independent Pathways Proceedings of the National Academy of Sciences of the United States of America · 2000
    29. Transforming Growth Factor-β Receptor Type I and Type II Expression During Murine Hair Follicle Development and Cycling Journal of Investigative Dermatology · 1997
    30. Interleukin 6: Insights Into Its Function in Skin by Overexpression in Transgenic Mice Proceedings of the National Academy of Sciences · 1992

    Related research 2

    1. The JAK/STAT Signaling Pathway: From Bench to Clinic Signal Transduction and Targeted Therapy · 2021
    2. Hair Follicle Expression of 1,25-Dihydroxyvitamin D3 Receptors During the Murine Hair Cycle British Journal of Dermatology · 2006