Pharmacologic Inhibition of JAK-STAT Signaling Promotes Hair Growth

    October 2015 in “ Science Advances ”
    Sivan Harel, Claire A. Higgins, Jane E. Cerise, Zhijun Dai, James C. Chen, Raphael Clynes, Angela M. Christiano
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    TLDR Blocking JAK-STAT signaling can lead to hair growth.
    The study from October 2, 2015, found that pharmacologic inhibition of the JAK-STAT signaling pathway promotes hair growth by inducing the anagen phase in hair follicles. Using topical treatments with JAK inhibitors like tofacitinib and ruxolitinib led to rapid hair growth in mouse and human skin. The study showed that JAK inhibition up-regulates genes associated with hair follicle inductivity and growth, such as those in the TGFB and BMP pathways. The effects were independent of lymphocyte activity, suggesting a direct action on hair follicles. The research involved experiments on mice and human hair follicle assays, but the number of subjects used in the experiments is not provided in the summary. The findings suggest potential new treatments for hair loss conditions by targeting the JAK-STAT pathway.
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      community What else is good. Besides the big 3.

      in Chat  34 upvotes 2 months ago
      Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

      community What 3 months without fin& min does😔

      in Progress Pictures  261 upvotes 1 month ago
      Stopping minoxidil and finasteride for three months caused significant hair loss. The user resumed treatment with 2.5mg oral minoxidil and 0.6mg finasteride and plans to update on progress in three months.

      community No idea what's causing my hair thinning

      in Chat  2 upvotes 2 months ago
      The user is experiencing diffuse hair thinning despite using finasteride and oral minoxidil, with no hairline recession or bald spots. Suggestions include checking for telogen effluvium, considering a JAK inhibitor for potential autoimmune issues, and conducting further tests to rule out other causes.

      community DUPA - 20 YO - Non responder to everything

      in Finasteride/Dutasteride  13 upvotes 3 months ago
      A 20-year-old user experienced worsening hair loss despite using various treatments including topical and oral minoxidil, finasteride, and dutasteride. Other users suggested additional treatments like JAK inhibitors, RU58841, and lifestyle changes, but the user remains skeptical and frustrated.

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