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Large-Scale Skin scRNA-Seq Profiling Highlights Distinct Body Site-Specific Ligand-Receptor Interactions and Pathways in Keratinocytes

research Large-Scale Skin scRNA-Seq Profiling Highlights Distinct Body Site-Specific Ligand-Receptor Interactions and Pathways in Keratinocytes

August 2023 in “Journal of Investigative Dermatology”

Different body areas have unique skin cell communication patterns, explaining why certain skin diseases occur in specific regions.

research In Vitro Hair Dermal Papilla Cells Induction by Fagraea Berteroana, a Tree of the Marquesan Cosmetopoeia (French Polynesia)

1 citations, February 2021 in “Cosmetics”

Fagraea berteroana fruit extract may promote hair growth by affecting cell proliferation and hair growth pathways.

research Pharmacologic Inhibition of JAK-STAT Signaling Promotes Hair Growth

159 citations, October 2015 in “Science Advances”

Blocking JAK-STAT signaling can lead to hair growth.

research Comparative Study on Seasonal Hair Follicle Cycling by Analysis of the Transcriptomes from Cashmere and Milk Goats

25 citations, February 2019 in “Genomics”

Cashmere and milk goats have different hair growth cycles and gene expressions, which could help improve wool production.

research Role of Stem/Progenitor Cells in Reparative Disorders

29 citations, December 2012 in “Fibrogenesis & Tissue Repair”

Adult stem cells are important for tissue repair and have therapeutic potential, but more research is needed to fully use them.

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community Opinions on Scalp fibrosis and DHT?

in Research/Science 9 upvotes 2 years ago

The conversation discusses the theory that scalp fibrosis contributes to male pattern baldness (MPB) by increasing DHT concentration, and mentions treatments like Minoxidil. The user seeks opinions on the theory and the effectiveness of scalp massages.

community HLT Megathread on HMI-115 (key takeaways in comments)

in Research/Science 40 upvotes 1 year ago

HMI-115, a newly discovered hair loss treatment that could potentially be effective for those with diffuse thinning and telogen effluvium. It is based on prolactin receptor antagonist signaling and has already undergone Phase I trials in women, with potential commercialization by 2027.

community Hair loss causes are still a myth.

in Chat 16 upvotes 3 years ago

The conversation discusses the complexity of hair loss causes, suggesting that DHT sensitivity alone doesn't fully explain it. Treatments mentioned include finasteride and dutasteride.

community The Real Cause Of Androgenetic Alopecia

in Research/Science 667 upvotes 1 month ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community UPDATE: The theory that explains everything. Please help me make this big!

in Research/Science 449 upvotes 3 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.

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