Role of Stem/Progenitor Cells in Reparative Disorders

    December 2012 in “ Fibrogenesis & Tissue Repair ”
    Thavaneetharajah Pretheeban, Darío R. Lemos, Benjamin Paylor, Regan-Heng Zhang, Fábio Rossi
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    TLDR Adult stem cells are important for tissue repair and have therapeutic potential, but more research is needed to fully use them.
    The document from 2012 reviews the role of adult stem cells, particularly mesenchymal stromal cells (MSCs) and tissue-specific resident stem cells (TSCs), in tissue repair and reparative disorders. It explains how these cells contribute to tissue regeneration or the formation of stromal scars during injury or disease. The review highlights the involvement of MSCs in various tissues and the importance of signaling pathways like TGFB, BMP, and Wnt in regulating the fate of these cells. It also discusses the therapeutic potential of these cells in treating disorders related to skeletal muscle, heart, and lung tissues, and notes the need for further research to understand the molecular mechanisms controlling their behavior in the reparative process. The document concludes that MSCs have a significant role in both successful tissue regeneration and reparative disorders, with advances suggesting their therapeutic potential, but more investigation is required to fully harness their capabilities.
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