In Vitro Hair Dermal Papilla Cells Induction by Fagraea Berteroana, a Tree of the Marquesan Cosmetopoeia (French Polynesia)
February 2021
in “
Cosmetics
”
TLDR Fagraea berteroana fruit extract may promote hair growth by affecting cell proliferation and hair growth pathways.
The study explored the potential of Fagraea berteroana, a tree from French Polynesia, for promoting hair growth. It found that an ethyl acetate extract of the fruit, particularly the FEAE-F0 fraction, induced dose-dependent proliferation of human hair follicle dermal papilla cells. FEAE-F0 down-regulated BMP2 and upregulated CCND1 gene expression, suggesting it affects the Wnt and TGFB pathways involved in hair growth. The fraction also increased nuclear ß-catenin, indicating an active hair growth state. Chemical analysis revealed the presence of an iridoid, boonein, and potential terpenoid structures. The results, based on at least three independent experiments with a p-value ≤ 0.05, suggest that FEAE-F0 could be a promising natural ingredient for hair care products. Further in vivo and ex vivo studies are recommended to confirm these findings and assess the potential of F. berteroana for preventing hair loss.
