Hair Growth Activity of Three Plants of the Polynesian Cosmetopoeia and Their Regulatory Effect on Dermal Papilla Cells
September 2020
in “
Molecules
”
TLDR Extracts from three Polynesian plants were found to promote hair growth by affecting cell growth and gene expression related to hair.
The study explored the effects of extracts from three Polynesian plants—Bidens pilosa, Calophyllum inophyllum, and Fagraea berteroana—on hair growth by examining their impact on dermal papilla cells (DPCs). The extracts were found to significantly increase the proliferation of DPCs and influence the expression of genes related to hair growth. Chemical analysis revealed the presence of compounds such as flavonoids, iridoids, and organic acids, which are associated with hair growth properties. The study demonstrated that specific extracts and fractions from these plants could upregulate genes that stimulate hair follicle proliferation and downregulate genes that inhibit hair growth. Additionally, the extracts showed antioxidant and anti-inflammatory activities, with certain fractions of C. inophyllum displaying significant effects. The findings suggest that these plant extracts have the potential to promote hair growth by affecting cell proliferation and gene expression related to hair growth pathways. However, the study was based on cellular assays and did not involve clinical trials, so further research is needed to confirm these effects in humans.
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