Wnt5a Suppresses β-Catenin Signaling During Hair Follicle Regeneration

    January 2016 in “ International Journal of Medical Sciences ”
    Yizhan Xing, Xiaogen Ma, Haiying Guo, Fang Ming Deng, Jin Yang, Yu Hong Li
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    TLDR Wnt5a slows down hair growth by blocking a specific pathway during hair regeneration.
    The study found that Wnt5a suppresses the activation of the canonical Wnt/β-catenin signaling pathway during hair follicle regeneration, inhibiting hair growth. The study used experiments on mice to demonstrate this, and suggests that Wnt5a could be a potential target for hair loss treatments. The study also found that the canonical Wnt signaling pathway is necessary for hair follicle regeneration.
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