Effect of Sinapic Acid on Hair Growth Promotion in Human Hair Follicle Dermal Papilla Cells via Akt Activation

March 2017 in “ Archives of Dermatological Research ”

Hyunju Woo, Seungjun Lee, Seungbeom Kim, Deokhoon Park, Eunsun Jung

sinapic acid hair follicle dermal papilla cells Akt signaling pathway IGF-1 VEGF phospho-GSK-3ß ß-catenin alopecia cell cycle progression SA hHFDPC insulin-like growth factor 1 vascular endothelial growth factor GSK-3B

TLDR Sinapic acid may help hair growth by activating a specific cell pathway.

The document from March 20, 2017, investigated the effects of sinapic acid (SA) on hair growth by studying its impact on human hair follicle dermal papilla cells (hHFDPC). The study demonstrated that SA treatment led to the proliferation of hHFDPCs and activated the Akt signaling pathway. It also increased the expression of growth factors such as IGF-1 and VEGF, which are crucial for hair growth, and promoted cell cycle progression by increasing phospho-GSK-3ß and accumulation of ß-catenin. These findings suggest that SA has the potential to be an effective treatment for alopecia by promoting hair growth through the activation of Akt and the subsequent inactivation of the GSK-3B/ß-catenin pathway. The study did not specify the number of people or cells used in the research.

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