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research Efficacy and safety of ritlecitinib in adults and adolescents with alopecia areata: a randomised, double-blind, multicentre, phase 2b–3 trial

227 citations , April 2023 in “The Lancet”

Ritlecitinib effectively treats alopecia areata and is well-tolerated.

research Safety and efficacy of the JAK inhibitor tofacitinib citrate in patients with alopecia areata

222 citations , September 2016 in “JCI insight”

This research overview highlights that although JAK inhibitors show promise as potential treatments for alopecia areata based on recent insights into the disease mechanism, their efficacy has not yet been thoroughly evaluated in a systematic manner.

A Phase IIA Randomized, Placebo-Controlled Clinical Trial to Study the Efficacy and Safety of the Selective Androgen Receptor Modulator (SARM), MK-0773 in Female Participants with Sarcopenia

research A phase IIA randomized, placebo-controlled clinical trial to study the efficacy and safety of the selective androgen receptor modulator (SARM), MK-0773 in female participants with sarcopenia

211 citations , May 2013 in “Journal of Nutrition Health & Aging”

This study found that while MK-0773 significantly increased lean body mass in sarcopenic frail elderly women, it did not significantly improve muscle strength or physical function compared to placebo.

Safety and Efficacy of Nucleic Acid Polymers in Monotherapy and Combined with Immunotherapy in Treatment-Naive Bangladeshi Patients with HBeAg Positive Chronic Hepatitis B Infection

research Safety and Efficacy of Nucleic Acid Polymers in Monotherapy and Combined with Immunotherapy in Treatment-Naive Bangladeshi Patients with HBeAg+ Chronic Hepatitis B Infection

176 citations , June 2016 in “PLoS ONE”

In these initial clinical studies, NAP monotherapy showed significant reductions in HBsAg levels among patients with chronic HBV, suggesting potential as part of future combination therapies.

research Functional salivary gland regeneration by transplantation of a bioengineered organ germ

165 citations , October 2013 in “Nature Communications”

This study demonstrates that bioengineered salivary gland transplants can fully regenerate gland function, producing saliva and restoring normal swallowing in salivary gland-defective mice, offering potential for xerostomia treatment.

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Community Join

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community Salicylic Acid shampoo while on minoxidil. Is it okay?

15 upvotes 5 years ago

Minoxidil users can safely use salicylic acid shampoo to manage scalp pimples and dandruff. Nizoral is also recommended for hair gain and treating scalp pimples.

community Anyone started with saw Palmetto to prepare their body for finasteride ?

2 upvotes 2 days ago

Saw palmetto may reduce DHT by 25-30%. Users discuss gradually increasing finasteride dosage to manage anxiety about side effects.

community Safe to microneedle+minox+tretinoin?

1 upvotes 1 week ago

The conversation discusses the safety of combining microneedling with minoxidil and tretinoin for hair loss treatment. It advises against using minoxidil immediately after microneedling due to infection and side effect risks, suggesting a 24-hour wait.

community Has any effect of sauna been demonstrated to worsen/ improve mpb?

1 upvotes 1 week ago

Sauna use may help with stress-related scalp issues and potentially improve hair health, but its effects on hair loss are unclear. Some users report positive experiences, while others remain uncertain about its impact.

community Sapphire FUE with Shannon Smeltzer — Excellent Results

in Hair Transplants 53 upvotes 1 week ago

The user is pleased with their Sapphire FUE hair transplant performed by Shannon Smeltzer, highlighting the natural-looking hairline and the convenience of having the procedure done locally in the Florida Keys. The AI system used in the procedure effectively selected the best grafts, resulting in excellent results.

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Learn

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learn Saw Palmetto

a natural and far less effective alternative to Finasteride

Is saw palmetto as effective as finasteride against DHT? Finasteride is more effective than saw palmetto in reducing DHT levels.
Is it better to take saw palmetto in capsules or use it in lotions? The evidence does not show one form is better: the only head-to-head hair study of oral saw palmetto compared it with finasteride (and finasteride did better), the topical evidence is a single uncontrolled pilot, and there is no trial comparing capsules with lotions.
Is saw palmetto good for androgenetic alopecia or only for mild hair loss? Saw palmetto may help with androgenetic alopecia, not just mild hair loss.
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