Protopanaxatriol Type Ginsenoside Re Promotes Cyclic Growth of Hair Follicles via Inhibiting Transforming Growth Factor β Signaling Cascades

    January 2016 in “ Biochemical and Biophysical Research Communications ”
    Zheng Li, Seung-Wook Ryu, Jungsul Lee … Chulhee Choi
    Studysummary In this study, researchers found that ginsenoside Re from Panax ginseng increased hair shaft length and duration in mice, comparable to minoxidil, by modulating TGF-β signaling pathways.
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    Research cited in this study 10

    1. Topical Application of Oleuropein Induces Anagen Hair Growth in Telogen Mouse Skin PLOS ONE · 2015
    2. A Simple and Rapid Model for Hair-Follicle Regeneration in the Nude Mouse Clinical and Experimental Dermatology · 2015
    3. Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation Cell stem cell · 2012
    4. Fructus Panax Ginseng Extract Promotes Hair Regeneration in C57BL/6 Mice Journal of Ethnopharmacology · 2011
    5. Effects of Ginseng Rhizome and Ginsenoside Ro on Testosterone 5α-Reductase and Hair Regrowth in Testosterone-Treated Mice Phytotherapy Research · 2011
    6. KGF And EGF Signaling Block Hair Follicle Induction And Promote Interfollicular Epidermal Fate In Developing Mouse Skin Development · 2009
    7. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    8. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007
    9. The Hair Cycle Journal of Cell Science · 2006
    10. Epidermal Growth Factor as a Biological Switch in Hair Growth Cycle Journal of biological chemistry/˜The œJournal of biological chemistry · 2003

    Related research 8

    1. Ginseng in Hair Growth and Viability IntechOpen eBooks · 2021
    2. MiR-140-5p in Small Extracellular Vesicles From Human Papilla Cells Stimulates Hair Growth by Promoting Proliferation of Outer Root Sheath and Hair Matrix Cells Frontiers in cell and developmental biology · 2020
    3. Effects of a Gintonin-Enriched Fraction on Hair Growth: An In Vitro and In Vivo Study Journal of Ginseng Research · 2019
    4. Hair-Growth Potential of Ginseng and Its Major Metabolites: A Review on Its Molecular Mechanisms International Journal of Molecular Sciences · 2018
    5. Protopanaxatriol Type Ginsenoside Re Promotes Cyclic Growth of Hair Follicles via Inhibiting Transforming Growth Factor β Signaling Cascades Biochemical and Biophysical Research Communications · 2016
    6. Towards Dissecting the Pathogenesis of Retinoid-Induced Hair Loss: All-Trans Retinoic Acid Induces Premature Hair Follicle Regression by Upregulation of Transforming Growth Factor-β2 in the Dermal Papilla Journal of Investigative Dermatology · 2005
    7. Expression of E6 and E7 Papillomavirus Oncogenes in the Outer Root Sheath of Hair Follicles Extends the Growth Phase and Bypasses Resting at Telogen PubMed · 2000
    8. Growth Factors in Hair Organ Development and the Hair Growth Cycle Dermatologic Clinics · 1996