Effects of a Gintonin-Enriched Fraction on Hair Growth: An In Vitro and In Vivo Study

    June 2019 in “ Journal of Ginseng Research
    Na Mi Lee, Sang-Deuk Park, Hongik Hwang, Sun-Hye Choi, Sa Ra Lee, Sung Sik Nam, Jong Young Choi, Hyewhon Rhim, Ik-Hyun Cho, Hyoung-Chun Kim, Sung Oh Hwang, Seung-Yeol Nah
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    TLDR Gintonin-enriched fraction promotes hair growth and could be a potential alopecia treatment.
    The study from 2020 investigated the effects of a gintonin-enriched fraction (GEF) on hair growth, using both human hair follicle dermal papilla cells (HFDPCs) in vitro and six-week-old male C57BL/6 mice in vivo. The in vitro results indicated that GEF induced calcium influx in HFDPCs, which in turn stimulated cell proliferation and vascular endothelial growth factor (VEGF) release. In vivo, mice treated with GEF showed dose-dependent improvements in hair growth, similar to those treated with minoxidil. GEF increased the number of hair follicles and hair weight in mice. The study concluded that GEF promotes hair growth by stimulating HFDPC proliferation and could be a potential treatment for human alopecia. However, the specific number of participants or subjects used in the study was not mentioned in the summary provided.
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