Topical Minoxidil Counteracts Stress-Induced Hair Growth Inhibition in Mice

September 2003 in “ Experimental Dermatology ”

Petra C. Arck, Bori Handjiski, Eva M.J. Peters, Evelin Hagen, Burghard F. Klapp, Ralf Paus

topical minoxidil stress-induced hair loss catagen development hair growth inhibition Rogaine

TLDR Minoxidil helps prevent stress-caused hair loss in mice.

A study from 2003 investigated the effect of stress on hair growth in mice and whether topical minoxidil could counteract this inhibition. The study found that stress negatively affects hair growth and leads to premature catagen development and hair loss. However, daily application of 5% minoxidil was found to counteract the effects of stress on hair growth and prevent premature catagen development. The study suggests that topical minoxidil may be a potential treatment for stress-induced hair loss in humans.

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Research cited in this study

13 / 13 results

Indications for a Brain-Hair Follicle Axis: Inhibition of Keratinocyte Proliferation and Up-Regulation of Keratinocyte Apoptosis in Telogen Hair Follicles by Stress and Substance P

research Indications for a Brain-Hair Follicle Axis: Inhibition of Keratinocyte Proliferation and Up-Regulation of Keratinocyte Apoptosis in Telogen Hair Follicles by Stress and Substance P

125 citations, September 2001 in “The FASEB Journal”

Stress can cause hair loss by negatively affecting hair follicles and this effect might be reversed with specific treatments.

research Treatments for Androgenetic Alopecia and Alopecia Areata

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Minoxidil and finasteride treat hair loss; more research needed for other options.

research Diffuse Hair Loss: Causes, Diagnosis, and Treatment

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Hair loss that spreads out can often fix itself or be treated by finding and handling the cause.

research Hair Follicle Elongation in Organ Culture of Skin from Newborn and Adult Mice

23 citations, May 1998 in “Journal of Dermatological Science”

Insulin or IGF-I is needed for hair growth in newborn mice, while minoxidil helps adult mouse hair grow, suggesting a way to study human hair loss.

Activation of Cytoprotective Prostaglandin Synthase-1 by Minoxidil as a Possible Explanation for Its Hair Growth-Stimulating Effect

research Activation of Cytoprotective Prostaglandin Synthase-1 by Minoxidil as a Possible Explanation for Its Hair Growth-Stimulating Effect

81 citations, February 1997 in “Journal of Investigative Dermatology”

Minoxidil boosts hair growth by activating PGHS-1.

research Neural Mechanisms of Hair Growth Control

101 citations, January 1997 in “Journal of Investigative Dermatology Symposium Proceedings”

Nerves and chemicals in the body can affect hair growth and loss.

research Whole Hair Follicle Culture

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HA-MNs with MXD effectively treat hair loss better than topical MXD with fewer side effects.

research Hair Follicle Stem Cells: Their Location, Role in Hair Cycle, and Involvement in Skin Tumor Formation

85 citations, July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology”

research Topical Minoxidil in Alopecia Areata: No Effect on the Perifollicular Lymphoid Infiltration

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Minoxidil doesn't affect perifollicular lymphoid infiltration in alopecia areata patients.

research Minoxidil Stimulates Mouse Vibrissae Follicles in Organ Culture

121 citations, March 1989 in “Journal of Investigative Dermatology”

Minoxidil can help grow hair in mice by making cells grow and improving hair quality. More research needed.

research Effect of Minoxidil on Pre- and Postconfluent Keratinocytes

22 citations, March 1987 in “Journal of The American Academy of Dermatology”

Minoxidil prolongs cell life, slows aging, and may produce longer hairs.

research Psychosomatic Concepts in Dermatology

143 citations, June 1983 in “Archives of dermatology”

Mental and social factors greatly affect skin conditions and doctors find it hard to deal with these aspects.

research Reversal of Baldness in Patient Receiving Minoxidil for Hypertension

95 citations, December 1980 in “The New England Journal of Medicine”

Minoxidil helped bald patient regrow hair.

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