Diffuse Hair Loss: Causes, Diagnosis, and Treatment

    Rodney Sinclair
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    TLDR Hair loss that spreads out can often fix itself or be treated by finding and handling the cause.
    In 1999, Rodney Sinclair, MD, discussed diffuse nonscarring telogen hair loss, a condition where anagen hairs prematurely enter the telogen phase, leading to excessive shedding. This can be triggered by events like illness, pregnancy, medication changes, or stress, and is usually self-limiting, resolving within 3-6 months. Chronic telogen effluvium, lasting beyond 6 months, may be related to iron deficiency or thyroid disorders. Treatment involves addressing the underlying cause and possibly using minoxidil. The document also covers hair loss due to metabolic disorders, drug-induced alopecia, androgenetic alopecia, and diffuse alopecia areata, with varying prognoses. Diagnosis is typically through patient history and blood tests, with scalp biopsies in unclear cases. Correct diagnosis is crucial for effective treatment, and most conditions, except chronic telogen effluvium, can be halted with appropriate intervention.
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      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Topical Minoxidil is a pain in the ass for diffuse thinners

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      Topical minoxidil being a difficult product to apply, with users considering finasteride, RU58841, and oral minoxidil as alternative treatments for diffuse thinning hair. Other advice includes shaving the head in the first 3 months of using minoxidil and finding ways to apply it without saturating the hair.

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      Lichen Planopilaris (LPP), a form of permanent hair loss, which can be mistaken for seborrheic dermatitis and is characterized by scalp itching, burning, redness, and dandruff. Treatment options discussed include steroidal creams, finasteride, minoxidil, and RU58841.

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