a signaling molecule from dermal papilla cells being actively researched
- How does SCUBE3 work on hair follicles compared to treatments like minoxidil or finasteride? Laboratory research in mice reports that SCUBE3, a protein released by dermal papilla cells, signals dormant follicles to grow through the TGF-β pathway downstream of Hedgehog; minoxidil and finasteride instead work on blood flow to the follicle and on DHT, and unlike SCUBE3 they have decades of human trial data behind them. SCUBE3 has not been tested in human clinical trials and is not available as a medicine.
extract, clone, and reinsert your own hair cells
compound that activates Wnt/β-catenin to promote hair regrowth and create new hair follicles
signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss
- Can long-term use of Fluocinolone affect the health of hair follicles? There is no long-term human trial measuring what topical fluocinolone does to hair follicles; what is documented is the label's warning about skin atrophy with prolonged use, plus a 2007 mouse study suggesting hair-follicle bulge stem cells do not repair steroid-induced atrophy.