3-Deoxysappanchalcone Promotes Proliferation of Human Hair Follicle Dermal Papilla Cells and Hair Growth in C57BL/6 Mice by Modulating WNT/β-Catenin and STAT Signaling

    October 2016 in “ Biomolecules & Therapeutics ”
    Young Eun Kim, Hyung Chul Choi, In Chul Lee, Dong Yeon Yuk, Hyosung Lee, Bu Young Choi
    Image of study
    TLDR 3-Deoxysappanchalcone helps human hair cells grow and stimulates hair growth in mice by affecting certain cell signaling pathways.
    The study from November 1, 2016, demonstrated that 3-Deoxysappanchalcone (3-DSC) promotes the proliferation of human hair follicle dermal papilla cells and stimulates hair growth in C57BL/6 mice. The research showed that 3-DSC modulates WNT/β-catenin and STAT signaling pathways, enhancing the phosphorylation of β-catenin and STAT3, and increasing the expression of hair growth-related genes such as Cdk4, FGF, and VEGF. Conversely, it reduced STAT6 mRNA expression and IL4-induced STAT6 phosphorylation. In mice, topical application of 3-DSC for 15 days resulted in rapid and intense hair growth. The study concluded that 3-DSC could be a potential therapeutic agent for hair growth, although the number of human participants was not specified, the number of mice used in the hair growth experiment was 8 (n=4 per group).
    Discuss this study in the Community →

    Research cited in this study

    15 / 15 results

    Related Community Posts Join

    6 / 1000+ results

      community 3 Months on “Phoenix” 2-in-1 pill (1mg fin + 3mg min oral)

      in Product  1 upvotes 2 days ago
      The user is taking a 2-in-1 pill containing 1mg finasteride and 3mg minoxidil daily, noticing some hair thickening and new hair growth but minimal progress at the back of the head. They are considering adding topical minoxidil or increasing dosage and are unsure if they should change their routine or wait for more results.

      community 3 Months on Dutasteride and Minoxidil!

      in Is this regrowth?  24 upvotes 2 weeks ago
      The user has been using Dutasteride, Minoxidil, and Biotin for three months and believes there is some hair regrowth, especially at the crown, with no significant side effects. Other users suggest that while some thickening and minor growth are visible, more time is needed for full results.

      community 3 months update (oral fin/min 1.2/3mg)

      in Progress Pictures  11 upvotes 2 weeks ago
      The user started using finasteride and minoxidil in October 2025 and noticed hair growth and thickening after three months, despite initial concerns about side effects. They are hopeful for continued progress and grateful for the support from the forum community.

      community 3 Months on Topical DUT & MIN Female Pattern Baldness

      in Progress Pictures  2 upvotes 3 weeks ago
      A user shared progress on treating female pattern baldness with a topical solution containing Minoxidil, Dutasteride, Tretinoin, Ketoconazole, and Hydrocortisone, along with supplements like Collagen Peptides, NAC, Vitamin C, and Keratin. Another user commented on the impressive results, noting the use of topical Dutasteride.

      community 3 months min/fin, kinda consistent

      in Is this regrowth?  8 upvotes 1 month ago
      A 29-year-old male experiencing hair loss started using oral minoxidil and finasteride three months ago, along with keto shampoo, and notices slight progress despite inconsistent use. He plans to continue this regimen for a year.

    Related Research

    1 / 1 results