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GlossaryCyclin-Dependent Kinase 4 (CDK4)

regulates cell cycle progression from G1 to S phase

Cyclin-Dependent Kinase 4 (CDK4) is an enzyme that plays a crucial role in regulating the cell cycle, specifically the transition from the G1 phase to the S phase, where the cell prepares to replicate its DNA. It forms a complex with cyclin D, and this complex is essential for the progression of cells through the cell cycle, making it a key player in cell division and growth. Dysregulation of CDK4 activity is often associated with various cancers, as it can lead to uncontrolled cell proliferation.

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research Cyclin-Dependent Kinase 4 Expression Alters the Number of Keratinocyte Stem Cells in the Mouse Hair Follicle

1 citations , January 2022 in “Cell Biology International”

Changing CDK4 levels affects the number of stem cells in mouse hair follicles.

research Kaempferol Enhances Hair Growth by Regulating JAK3/STAT6 and TGF-β/Smad Signaling in Human Dermal Papilla Cells and a C57BL/6 Mouse Model

October 2025 in “Records of Natural Products”

Kaempferol promotes hair growth and could be a natural treatment for hair loss.

3-Deoxysappanchalcone Promotes Proliferation of Human Hair Follicle Dermal Papilla Cells and Hair Growth in C57BL/6 Mice by Modulating WNT/β-Catenin and STAT Signaling

research 3-Deoxysappanchalcone Promotes Proliferation of Human Hair Follicle Dermal Papilla Cells and Hair Growth in C57BL/6 Mice by Modulating WNT/β-Catenin and STAT Signaling

26 citations , October 2016 in “Biomolecules & Therapeutics”

3-Deoxysappanchalcone helps human hair cells grow and stimulates hair growth in mice by affecting certain cell signaling pathways.

research Hair Growth Promoting Effect of 4HGF Encapsulated with PGA Nanoparticles by β-Catenin Activation and Related Cell Cycle Molecules

7 citations , July 2019 in “International Journal of Molecular Sciences”

PGA-4HGF may help treat hair loss by activating hair growth pathways and extending the hair growth phase.

research Molecular Regulation of Melanocyte Senescence

85 citations , July 2002 in “Pigment Cell Research”

The article concludes that while we understand a lot about how melanocytes age and how this can prevent cancer, there are still unanswered questions about certain pathways and genes involved.

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