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    GlossaryCyclin-Dependent Kinase 4 (CDK4)

    regulates cell cycle progression from G1 to S phase

    Cyclin-Dependent Kinase 4 (CDK4) is an enzyme that plays a crucial role in regulating the cell cycle, specifically the transition from the G1 phase to the S phase, where the cell prepares to replicate its DNA. It forms a complex with cyclin D, and this complex is essential for the progression of cells through the cell cycle, making it a key player in cell division and growth. Dysregulation of CDK4 activity is often associated with various cancers, as it can lead to uncontrolled cell proliferation.

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