Calcineurin/NFATc1 Signaling Links Skin Stem Cell Quiescence to Hormonal Signaling During Pregnancy and Lactation

    April 2014 in “ Genes & Development ”
    Jill M. Goldstein, Sean A. Fletcher, Eve Roth, Chuansha Wu, Andrew S. Chun, Valerie Horsley
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    TLDR Hormones during pregnancy and lactation keep skin stem cells inactive, preventing hair growth.
    The study from April 14, 2014, explored how calcineurin/Nfatc1 signaling affects hair follicle stem cell (HF SC) quiescence during pregnancy and lactation in mice. It was found that this signaling pathway regulates the expression of the prolactin receptor (Prlr) and that high serum prolactin levels during pregnancy and lactation activate Prlr, leading to HF SC quiescence through Jak/Stat5 signaling. The study demonstrated that prolactin signaling is crucial for maintaining SC quiescence in the skin, which prevents hair growth during these periods. The research also showed that inhibiting Prl signaling can lead to premature hair regrowth, suggesting that hormonal signals are key in controlling SC activity and hair cycle. The study used various experimental approaches, including genetic and pharmacological manipulations, but the exact number of mice used was not specified.
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