Hair Loss and Hyperprolactinemia in Women

    January 2012 in “ Dermato-endocrinology ”
    G. Lutz
    Image of study
    TLDR Moderately high prolactin levels do not cause hair loss in women.
    The document from 2012 examines the connection between hyperprolactinemia and hair loss in women. It includes a study of 40 women with diffuse alopecia, where 82.5% had diffuse hair loss and 17.5% had androgenetic alopecia. Prolactin levels varied, with most below 50 ng/ml, and 15 patients with elevated levels showed reductions without medication. The study concluded that moderate elevated prolactin levels are not causative for hair loss and do not affect the pattern, extent, or duration of hair loss. It also suggests that severe hyperprolactinemia may be involved in hair loss and that persistent elevated levels could indicate a prolactin-producing tumor, warranting further diagnostics. The document also reviews literature on the topic, with few studies over 30 years exploring this connection, and outlines the methods for evaluating hair loss and hyperprolactinemia, including the pluck trichogram and serological diagnostics. It emphasizes the need for accurate classification of hair loss and consideration of hyperprolactinemia among other potential causes.
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      community HLT Megathread on HMI-115 (key takeaways in comments)

      in Research/Science  40 upvotes 1 year ago
      HMI-115, a newly discovered hair loss treatment that could potentially be effective for those with diffuse thinning and telogen effluvium. It is based on prolactin receptor antagonist signaling and has already undergone Phase I trials in women, with potential commercialization by 2027.

      community hmi115 is coming. Prepare yourselves for what's coming

      in Technology  106 upvotes 1 year ago
      The conversation discusses HMI-115, a potential cure for hair loss. Users share mixed opinions, with some expressing skepticism and others sharing anecdotal evidence of its effectiveness, including photos of significant hair regrowth from a trial participant.

      community DHT levels after 4 weeks of Fina and 8 weeks of Fina + 4 weeks of Duta

      in Update  36 upvotes 5 years ago
      The user reported early stage diffuse hair thinning and increased DHT levels after 4 weeks on Finasteride and 8 weeks on Finasteride plus 4 weeks on Dutasteride, despite the medications being authentic and stored properly. They are considering increasing their Dutasteride dosage due to the lack of side effects and are unsure if the treatment is helping their hair.

      community does lowering your prolactin levels regrow hair?

      in Research/Science  11 upvotes 1 year ago
      The potential of lowering prolactin levels to regrow hair, with a reference to Bayer's drug HMI 115 which has been indicated as having this effect. Treatments mentioned include Minoxidil and Finasteride, as well as RU58841.

      community how about progesterone cream?

      in Research/Science  21 upvotes 6 months ago
      Progesterone cream might help with hair loss by inhibiting DHT production and suppressing prolactin, which can increase DHT. Some dermatologists have used progesterone for hair loss treatment, and it has been effective, sometimes combined with minoxidil, finasteride, and hydrocortisone.

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