Prolactin and the Skin: A Dermatological Perspective on an Ancient Pleiotropic Peptide Hormone

    December 2008 in “ Journal of Investigative Dermatology ”
    Kerstin Foitzik, Ewan A. Langan, Ralf Paus
    Studysummary This review discusses the possible impacts of prolactin on skin conditions like psoriasis, alopecia, and stress-related dermatoses, emphasizing the need for further research to explore its therapeutic potential.
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    Research cited in this study 14

    1. Hormonal Basis of Male and Female Androgenic Alopecia: Clinical Relevance Skin Pharmacology and Physiology · 2009
    2. Prolactin Delays Hair Regrowth in Mice Journal of Endocrinology · 2006
    3. Neuroimmunology of Stress: Skin Takes Center Stage Journal of Investigative Dermatology · 2006
    4. Human Scalp Hair Follicles Are Both a Target and a Source of Prolactin, Which Serves as an Autocrine and/or Paracrine Promoter of Apoptosis-Driven Hair Follicle Regression American Journal of Pathology · 2006
    5. Corticotropin-Releasing Hormone and the Skin Frontiers in bioscience · 2006
    6. Hair Growth Inhibition by Psychoemotional Stress: A Mouse Model for Neural Mechanisms in Hair Growth Control Experimental Dermatology · 2005
    7. Neuroimmunoendocrine Circuitry of the Brain-Skin Connection Trends in Immunology · 2005
    8. Human Hair Follicles Display a Functional Equivalent of the Hypothalamic-Pituitary-Adrenal (HPA) Axis and Synthesize Cortisol The FASEB Journal · 2005
    9. Acne and Sebaceous Gland Function Clinics in dermatology · 2004
    10. Prolactin and Its Receptor Are Expressed in Murine Hair Follicle Epithelium, Show Hair Cycle-Dependent Expression, and Induce Catagen American Journal of Pathology · 2003
    11. Molecular Genetic and Endocrine Mechanisms of Hair Growth Hormone Research in Paediatrics · 2003
    12. Prolactin Signaling Influences the Timing Mechanism of the Hair Follicle: Analysis of Hair Growth Cycles in Prolactin Receptor Knockout Mice Endocrinology · 2001
    13. Does Prolactin Play a Role in Skin Biology and Pathology? Medical hypotheses · 1991
    14. Hormonal Diagnosis of So-Called Androgenetic Alopecia in Women Geburtshilfe und Frauenheilkunde · 1988