Neuroimmunology of Stress: Skin Takes Center Stage

    July 2006 in “ Journal of Investigative Dermatology ”
    Petra C. Arck, Andrzej Slominski, Theoharis C. Theoharides … Ralf Paus
    Studysummary This review discusses the brain-skin connection, the skin's role in stress response, and highlights unmet challenges in understanding stress-induced skin inflammation but reports no new experimental findings.
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    Research cited in this study 11

    1. The Role of Melatonin in Neuroectodermal-Mesodermal Interactions: The Hair Follicle Synthesizes Melatonin and Expresses Functional Melatonin Receptors ˜The œFASEB journal · 2005
    2. Human Hair Follicles Display a Functional Equivalent of the Hypothalamic-Pituitary-Adrenal (HPA) Axis and Synthesize Cortisol The FASEB Journal · 2005
    3. Mast Cell Deficient and Neurokinin-1 Receptor Knockout Mice Are Protected from Stress-Induced Hair Growth Inhibition Journal of Molecular Medicine · 2005
    4. The Cutaneous Serotoninergic/Melatoninergic System: Securing a Place Under the Sun ˜The œFASEB journal · 2005
    5. Stress Exposure Modulates Peptidergic Innervation and Degranulates Mast Cells in Murine Skin Brain Behavior and Immunity · 2004
    6. Burden of Hair Loss: Stress and the Underestimated Psychosocial Impact of Telogen Effluvium and Androgenetic Alopecia Journal of Investigative Dermatology · 2004
    7. Neurogenic Inflammation in Stress-Induced Termination of Murine Hair Growth Is Promoted by Nerve Growth Factor American Journal of Pathology · 2004
    8. Topical Minoxidil Counteracts Stress-Induced Hair Growth Inhibition in Mice Experimental Dermatology · 2003
    9. Stress Inhibits Hair Growth in Mice by Inducing Premature Catagen Development and Harmful Perifollicular Inflammatory Events via Neuropeptide Substance P-Dependent Pathways American Journal of Pathology · 2003
    10. Expression of Hypothalamic-Pituitary-Thyroid Axis Related Genes in Human Skin Journal of Investigative Dermatology · 2002
    11. Indications for a Brain-Hair Follicle Axis: Inhibition of Keratinocyte Proliferation and Up-Regulation of Keratinocyte Apoptosis in Telogen Hair Follicles by Stress and Substance P The FASEB Journal · 2001