Stress Exposure Modulates Peptidergic Innervation and Degranulates Mast Cells in Murine Skin

    November 2004 in “ Brain Behavior and Immunity ”
    Eva M.J. Peters, Arne Kuhlmei, Desmond J. Tobin … Petra C. Arck
    Studysummary This study found that stress increases the number of peptidergic nerve fibers and mast cell activity in mouse skin, suggesting a significant neuro-immune interaction under stress.
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    Research cited in this study 6

    1. Stress Inhibits Hair Growth in Mice by Inducing Premature Catagen Development and Harmful Perifollicular Inflammatory Events via Neuropeptide Substance P-Dependent Pathways American Journal of Pathology · 2003
    2. Developmental Timing of Hair Follicle and Dorsal Skin Innervation in Mice Journal of comparative neurology · 2002
    3. Indications for a Brain-Hair Follicle Axis: Inhibition of Keratinocyte Proliferation and Up-Regulation of Keratinocyte Apoptosis in Telogen Hair Follicles by Stress and Substance P The FASEB Journal · 2001
    4. Hair-Cycle-Associated Remodeling of the Peptidergic Innervation of Murine Skin and Hair Growth Modulation by Neuropeptides Journal of Investigative Dermatology · 2001
    5. A Simple Immunofluorescence Technique for Simultaneous Visualization of Mast Cells and Nerve Fibers Reveals Selectivity and Hair Cycle-Dependent Changes in Mast Cell-Nerve Fiber Contacts in Murine Skin Archives of Dermatological Research · 1997
    6. Neural Mechanisms of Hair Growth Control Journal of Investigative Dermatology Symposium Proceedings · 1997