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Neuronal Plasticity of the Brain-Skin Connection: Stress-Triggered Up-Regulation of Neuropeptides in Dorsal Root Ganglia and Skin via Nerve Growth Factor-Dependent Pathways

research Neuronal Plasticity of the Brain-Skin Connection: Stress-Triggered Up-Regulation of Neuropeptides in Dorsal Root Ganglia and Skin via Nerve Growth Factor-Dependent Pathways

66 citations, July 2007 in “Journal of Molecular Medicine”

Stress increases certain chemicals in the skin and nerves, which might worsen skin conditions.

research Stress Exposure Modulates Peptidergic Innervation and Degranulates Mast Cells in Murine Skin

115 citations, November 2004 in “Brain Behavior and Immunity”

Stress increases nerve fibers and immune cell activity in mouse skin, possibly worsening skin conditions.

research Finasteride-Induced Depression: New Insights Into Possible Pathomechanisms

22 citations, December 2010 in “Journal of Cosmetic Dermatology”

Finasteride may increase depression by reducing brain cell growth.

research Finasteride Treatment Inhibits Adult Hippocampal Neurogenesis in Male Mice

32 citations, May 2010 in “Pharmacopsychiatry”

Finasteride reduces new brain cells in male mice, possibly causing depression.

research Spatiotemporal Dynamics of Sensory Neuron and Merkel-Cell Remodeling During Epidermal Homeostasis

May 2023

Sensory neurons and Merkel cells remodel at different rates during normal skin maintenance.

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community I think I’m on to something

23 upvotes 5 years ago

The user shared their personal experience with hair loss, hormone imbalances, and treatments including testosterone boosters, natural estrogen blockers, and DHEA. They suggest that low-dose finasteride and natural hormone therapy could reduce hair loss with fewer side effects.