The Role of Melatonin in Neuroectodermal-Mesodermal Interactions: The Hair Follicle Synthesizes Melatonin and Expresses Functional Melatonin Receptors

    July 2005 in “ ˜The œFASEB journal ”
    Hiromi Kobayashi, Arno Kromminga, Thomas W. Dunlop … Ralf Paus
    Studysummary This study found that hair follicles in both mice and humans may serve as an important site for melatonin synthesis and signaling, potentially influencing hair cycle regulation by modulating keratinocyte apoptosis.
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    Research cited in this study 20

    1. Substantial Sex-Dependent Differences in the Response of Human Scalp Hair Follicles to Estrogen Stimulation In Vitro Advocate Gender-Tailored Management of Female Versus Male Pattern Balding Journal of Investigative Dermatology Symposium Proceedings · 2005
    2. Hair Cycle Control by Estrogens: Catagen Induction via Estrogen Receptor Alpha Is Checked by ER Beta Signaling Endocrinology · 2005
    3. Expression and Functional Relevance of Melatonin Receptors in Hair Follicle Biology Experimental dermatology · 2005
    4. The Cutaneous Serotoninergic/Melatoninergic System: Securing a Place Under the Sun ˜The œFASEB journal · 2005
    5. Melatonin Increases Anagen Hair Rate in Women With Androgenetic Alopecia or Diffuse Alopecia: Results of a Pilot Randomized Controlled Trial British Journal of Dermatology · 2004
    6. Epithelial Growth Control by Neurotrophins: Leads and Lessons from the Hair Follicle Progress in brain research · 2004
    7. Characterization of the Serotoninergic System in the C57BL/6 Mouse Skin European journal of biochemistry · 2003
    8. Serotoninergic And Melatoninergic Systems Are Fully Expressed In Human Skin ˜The œFASEB journal · 2002
    9. 17β-Estradiol and ICI-182780 Regulate the Hair Follicle Cycle in Mice Through an Estrogen Receptor-α Pathway Endocrinology and metabolism/American journal of physiology: endocrinology and metabolism · 2000
    10. Role of Prolactin in Regulating the Onset of Winter Fur Growth in Mink: A Reconsideration ˜The œjournal of experimental zoology/Journal of experimental zoology · 1999
    11. The Biology of Hair Follicles The New England Journal of Medicine · 1999
    12. Serum Prolactin and Dehydroepiandrosterone Concentrations During the Summer and Winter Hair Growth Cycles of Mink (Mustela Vison) Comparative biochemistry and physiology. Part A, Molecular & integrative physiology · 1998
    13. Neural Mechanisms of Hair Growth Control Journal of Investigative Dermatology Symposium Proceedings · 1997
    14. An Estrogen Receptor Pathway Regulates the Telogen-Anagen Hair Follicle Transition and Influences Epidermal Cell Proliferation Proceedings of the National Academy of Sciences of the United States of America · 1996
    15. Seasonal Fiber Growth Cycles of Ferrets (Mustela Putorius Furo) and Long-Term Effects of Melatonin Treatment ˜The œjournal of experimental zoology/Journal of experimental zoology · 1995
    16. Human Hair Growth In Vitro: A Model for the Study of Hair Follicle Biology Journal of Dermatological Science · 1994
    17. Murine Skin as a Target for Melatonin Bioregulation Experimental dermatology · 1994
    18. Fiber Growth Initiation in Hair Follicles of Goats Treated with Melatonin ˜The œjournal of experimental zoology/Journal of experimental zoology · 1993
    19. Hair Growth Inhibition by Heparin in Mice: A Model System for Studying the Modulation of Epithelial Cell Growth by Glycosaminoglycans British Journal of Dermatology · 1991
    20. Post-Tyrosinase Inhibition of Melanogenesis by Melatonin in Hair Follicles In Vitro Journal of Investigative Dermatology · 1980

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