Expression and Functional Relevance of Melatonin Receptors in Hair Follicle Biology

January 2005 in “ Experimental dermatology ”

Hiroshi Kobayashi, Ralf Paus

melatonin receptors MT1 MT2 RORα hair follicle hair growth regulation alopecia cAMP TGF-B extracellular matrix human dermal fibroblasts hair cycle dynamics fibrosis melatonin hair loss hair growth hair follicles

TLDR Melatonin receptors in hair follicles help regulate hair growth and could treat hair loss.

The document discussed the expression and functional relevance of melatonin receptors in hair follicle biology, highlighting their role in hair growth regulation and potential use in treating hair loss conditions like alopecia. It provided evidence that melatonin receptors MT1, MT2, and RORα were present in murine hair follicles, with their expression varying according to the hair cycle. The study also noted that increased intracellular cAMP levels suppressed TGF-B-induced expression of extracellular matrix components in human dermal fibroblasts, suggesting that melatonin and related pathways could influence hair cycle dynamics and act as antagonists of fibrosis.

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community Anyone here get results from topical melatonin?

in Research/Science 11 upvotes 2 years ago

A user has been using finasteride and minoxidil for hair loss but is experiencing increased shedding and is considering using topical melatonin with a product called Rizn. Another user is skeptical about the effectiveness of topical melatonin due to issues with the research and lack of replication of results, while a third user expresses interest in the outcome of using Rizn after not seeing results from topical finasteride and minoxidil.

community 4 months after adding topical finasteride + melatonin, and switching from dermaroller to dr. Pen

in Treatment 225 upvotes 2 years ago

A user's experience using topical finasteride and melatonin to regrow hair, as well as their use of dermaroller versus dr. Pen for microneedling. People discussed the benefits of oral minoxidil and questioned if melatonin could help with hair regrowth.

community Optimal dose for topical Melatonin

in Treatment 6 upvotes 1 year ago

The conversation is about finding the optimal concentration of topical melatonin for hair loss treatment. The user is considering making their own solution and is unsure whether a higher concentration is more effective for deactivating prolactin receptors.

community Topical melatonin instead of fin

in Research/Science 8 upvotes 1 year ago

A 22-year-old man has been using topical melatonin for a year to slow hair loss and it appears to be effective. He's seeking alternatives to finasteride due to potential side effects, and is interested in understanding how melatonin works to prevent hair shedding.

community How all hormones affect our hair follicles. Not just DHT. Take a look at this paper. Prolactin, melatonin, cortisol, progesterone, testosterone and more

in Research/Science 126 upvotes 2 years ago

The conversation discusses various factors affecting hair loss, not just DHT, and mentions treatments like Minoxidil, finasteride, and melatonin. Some users report personal experiences with these treatments and hormone tests, while others speculate on the role of hormones like prolactin and cortisol in hair loss.

community Last resort attempt. Studies suggest that finasteride topically actually inhibits up to 52% scalp dht which is smiles to dut 0.5mg daily. This solution contains: fin, min, melatonin and progesterone. Trial started today.

in Research/Science 9 upvotes 2 years ago

The conversation discusses a last-resort hair loss treatment combining topical finasteride, minoxidil, melatonin, and progesterone, with claims that topical finasteride can inhibit up to 52% of scalp DHT. One reply clarifies that progesterone is not an anti-androgen but has anti-androgenic properties because it competes with androgens for receptors.

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Morphogenesis, Growth Cycle, and Molecular Regulation of Hair Follicles