Expression and Functional Relevance of Melatonin Receptors in Hair Follicle Biology

    January 2005 in “ Experimental dermatology ”
    Hiroshi Kobayashi, Ralf Paus
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    TLDR Melatonin receptors in hair follicles help regulate hair growth and could treat hair loss.
    The document discussed the expression and functional relevance of melatonin receptors in hair follicle biology, highlighting their role in hair growth regulation and potential use in treating hair loss conditions like alopecia. It provided evidence that melatonin receptors MT1, MT2, and RORα were present in murine hair follicles, with their expression varying according to the hair cycle. The study also noted that increased intracellular cAMP levels suppressed TGF-B-induced expression of extracellular matrix components in human dermal fibroblasts, suggesting that melatonin and related pathways could influence hair cycle dynamics and act as antagonists of fibrosis.
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