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Glossary Stress Hormones

chemicals released by the body in response to stress

Stress hormones are chemicals released by the body in response to stress, with cortisol and adrenaline being the most well-known examples. These hormones prepare the body to handle stressful situations by increasing heart rate, blood pressure, and energy supplies. Chronic elevation of stress hormones can negatively impact various bodily functions, including immune response and hair growth, potentially leading to conditions like alopecia.

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Research

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research Stress-induced Interaction of Skin Immune Cells, Hormones, and Neurotransmitters

88 citations , May 2020 in “Clinical therapeutics”

This review discusses the role of stress mediators in skin diseases and reports no new clinical results; the authors suggest further research in skin psychoneuroimmunology.

research Stress and reproductive hormones reflect inter-specific social and nutritional conditions mediated by resource availability in a bear-salmon system

66 citations , May 2014 in “Conservation Physiology”

This study found that lower salmon availability was associated with higher stress hormone levels in grizzly and black bears, influencing their physiological responses and competitive behaviors.

research Hair follicle is a target of stress hormone and autoimmune reactions

61 citations , September 2010 in “Journal of Dermatological Science”

This review discusses the interplay between hormonal and immune systems in hair follicles and reports no new results, highlighting the need for further research on their role in skin biology and alopecia areata.

research Immunoregulatory mechanisms and stress hormones in psoriasis (part 1)

16 citations , May 1998 in “International Journal of Dermatology”

This study found that elevated serum cortisol levels and other immunological changes are significantly involved in the active phases of psoriasis eruptions.

research Stressfulness of Medically Indicated Abortion as Reflected by Hair Concentrations of Stress Hormones Cortisol and Testosterone: A Pilot Study

January 2025

This study found that women undergoing mid-trimester termination of pregnancy exhibited increased cumulative cortisol and testosterone levels in hair samples, higher anxiety, but better stress coping strategies two months post-abortion, suggesting hair testosterone may be linked to emotional vulnerability such as neuroticism during this period.

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Community Join

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community A stress hormone has been found to signal through skin cells to repress the activation of hair-follicle stem cells in mice

30 upvotes 5 years ago

Stress can lead to hair loss by affecting hair-follicle stem cells, and this loss is harder to recover from if one has male pattern baldness (MPB). Treatments like finasteride and minoxidil are used to address hair loss, but stress-related hair loss differs from androgenic alopecia.

community Connection between caffeine and hair loss?

in Product 2 years ago

Caffeine might raise stress hormones, potentially worsening hair loss. Telogen effluvium is often misattributed to minor stressors rather than significant life events.

community 23M Wierd blood test results after 7 months on finasteroid (1mg daily)

5 upvotes 9 months ago

A user experienced unexpected hormone test results after 7 months on 1mg daily finasteride, noting a decrease in estradiol despite expectations of an increase. Other users suggested that hormone responses can vary and that finasteride might still be effective if DHT levels are within range, while also mentioning factors like circadian rhythm and stress that could impact results.

community Circadian rhythm disruption and its potential impact on hair growth cycles

in Technology 7 upvotes 4 months ago

Poor sleep quality may affect hair growth cycles by disrupting the body's natural clock and stress hormones. The focus should be on improving sleep to support overall health, including hair growth, rather than relying solely on treatments like Minoxidil, finasteride, or RU58841.

community Ray Peat: Testosterone Isn’t the Culprit, Prolactin and Cortisol Drive Hair Loss (2016)

in Research/Science 110 upvotes 11 months ago

Prolactin and cortisol are identified as key factors in hair loss, with stress hormones impacting hair shedding. Finasteride and minoxidil are effective treatments, while DHT's role and individual sensitivity are significant factors.

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Learn

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learn Clascoterone

Topical androgen-receptor blocker, approved as an acne cream

Does clascoterone have any side effects? Most reported side effects of clascoterone are skin irritation, but the acne-cream label also warns of stress-hormone (HPA-axis) suppression and raised potassium in some patients.

learn Caffeine

Stimulant used in hair shampoos and lotions

learn Dutasteride

5-alpha reductase inhibitor that blocks both enzyme types, a stronger DHT blocker than finasteride

learn Neem Oil

Oil from the neem tree, used in traditional remedies

learn PP405

Can PP405 help bald patches caused by stress? PP405 is an experimental topical gel from Pelage Pharmaceuticals that inhibits the mitochondrial pyruvate carrier; its registered Phase 2 trial (NCT06393452) tested it once daily in 78 adults with pattern hair loss, for safety and tolerability. It is not approved, not for sale, and has not been studied in alopecia areata or stress-related shedding.

learn Baricitinib

Can Baricitinib work if my hair loss is from stress or anxiety? Baricitinib is approved for severe alopecia areata in adults, an autoimmune condition. It has not been shown to work for stress-related shedding (telogen effluvium) and carries an FDA boxed warning.

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