Neurogenic Inflammation in Stress-Induced Termination of Murine Hair Growth Is Promoted by Nerve Growth Factor

July 2004 in “ American Journal of Pathology ”

Eva M.J. Peters, Bori Handjiski, Arne Kuhlmei, Edward H. Hagen, Hannes Bielas, Armin Braun, Burghard F. Klapp, Ralf Paus, Petra C. Arck

nerve growth factor NGF catagen apoptosis immune cells neurogenic inflammation stress-induced hair loss

TLDR Stress increases a factor in mice that leads to hair loss, and blocking this factor may prevent it.

In the 2004 study, researchers found that stress in mice leads to an increase in nerve growth factor (NGF) and changes in its receptors, which contributes to the premature onset of catagen, apoptosis, and activation of immune cells in the skin, indicating a stress response. Neutralizing NGF reduced these effects, suggesting that NGF is a key player in the neurogenic inflammation that causes stress-induced hair loss. The study involved groups of 10-11 mice and assessed at least 100 individual hair follicles per mouse, indicating a substantial sample size for the conclusions drawn. The findings imply that targeting NGF could be a therapeutic approach for stress-related hair loss conditions.

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Research cited in this study

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research Topical Minoxidil Counteracts Stress-Induced Hair Growth Inhibition in Mice

30 citations , September 2003 in “Experimental Dermatology”

Minoxidil helps prevent stress-caused hair loss in mice.

Stress Inhibits Hair Growth in Mice by Inducing Premature Catagen Development and Harmful Perifollicular Inflammatory Events via Neuropeptide Substance P-Dependent Pathways

research Stress Inhibits Hair Growth in Mice by Inducing Premature Catagen Development and Harmful Perifollicular Inflammatory Events via Neuropeptide Substance P-Dependent Pathways

194 citations , March 2003 in “American Journal of Pathology”

Stress stops hair growth in mice by causing early hair growth phase end and harmful inflammation through a specific nerve-related pathway.

research Noggin Is Required for Induction of the Hair Follicle Growth Phase in Postnatal Skin

211 citations , October 2001 in “The FASEB Journal”

Noggin is necessary to start the hair growth phase in skin after birth.

Indications for a Brain-Hair Follicle Axis: Inhibition of Keratinocyte Proliferation and Up-Regulation of Keratinocyte Apoptosis in Telogen Hair Follicles by Stress and Substance P

research Indications for a Brain-Hair Follicle Axis: Inhibition of Keratinocyte Proliferation and Up-Regulation of Keratinocyte Apoptosis in Telogen Hair Follicles by Stress and Substance P

125 citations , September 2001 in “The FASEB Journal”

Stress can cause hair loss by negatively affecting hair follicles and this effect might be reversed with specific treatments.

research Hair-Cycle-Associated Remodeling of the Peptidergic Innervation of Murine Skin and Hair Growth Modulation by Neuropeptides

112 citations , February 2001 in “Journal of Investigative Dermatology”

Neuropeptides affect hair growth, with some speeding it up and others slowing it down.

research A Role for p75 Neurotrophin Receptor in the Control of Apoptosis-Driven Hair Follicle Regression

96 citations , October 2000 in “The FASEB Journal”

The p75 neurotrophin receptor is important for hair follicle regression by controlling cell death.

research Keratinocyte Growth Factor Is an Important Endogenous Mediator of Hair Follicle Growth, Development, and Differentiation. Normalization of the Nu/Nu Follicular Differentiation Defect and Amelioration of Chemotherapy-Induced Alopecia.

219 citations , July 1995 in “PubMed”

Keratinocyte growth factor promotes hair growth and reduces hair loss from chemotherapy.

research Melanogenesis During the Anagen-Catagen-Telogen Transformation of the Murine Hair Cycle

161 citations , June 1994 in “The journal of investigative dermatology/Journal of investigative dermatology”

Hair stops producing melanin as it transitions from the growth phase to the resting phase.

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