The Hair Loss Encyclopedia

Keratinocyte Growth Factor Is an Important Endogenous Mediator of Hair Follicle Growth, Development, and Differentiation. Normalization of the Nu/Nu Follicular Differentiation Defect and Amelioration of Chemotherapy-Induced Alopecia.

July 1995 in “ PubMed ”

Dimitry M. Danilenko, Brian D. Ring, Donna Yanagihara, William G. Benson, B Wiemann, C.O. Starnes, Glenn F. Pierce

TLDR Keratinocyte growth factor promotes hair growth and reduces hair loss from chemotherapy.

The study demonstrated that keratinocyte growth factor (KGF or FGF-7) played a significant role in hair follicle growth, development, and differentiation. KGF and its receptor were highly expressed in skin, particularly in developing hair follicles. In experiments with nu/nu athymic nude mice, recombinant KGF (rKGF) induced dose-dependent hair growth and normalized follicular defects. Additionally, in a neonatal rat model of chemotherapy-induced alopecia, rKGF provided a dose-dependent protective effect, reducing alopecia by up to 50%. These findings suggested that KGF was a crucial endogenous factor in hair follicle biology.

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Research cited in this study

11 / 11 results

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research Mice With a Null Mutation of the TGFα Gene Have Abnormal Skin Architecture, Wavy Hair, and Curly Whiskers and Often Develop Corneal Inflammation

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research Targeting Expression of Keratinocyte Growth Factor to Keratinocytes Elicits Striking Changes in Epithelial Differentiation in Transgenic Mice

265 citations , March 1993 in “The EMBO Journal”

Keratinocyte growth factor significantly alters skin and tissue development.

research Differences in activity of minoxidil and cyclosporin A on hair growth in nude and normal mice. Comparisons of in vivo and in vitro studies.

35 citations , January 1990 in “PubMed”

Cyclosporin A boosts hair growth in nude mice, but minoxidil does not.

research Cyclosporin A stimulates hair growth in nude mice.

55 citations , June 1987 in “PubMed”

Cyclosporin A significantly increases hair growth in certain areas of mice.

Topical Minoxidil Therapy in Hereditary Androgenetic Alopecia

research Topical Minoxidil Therapy in Hereditary Androgenetic Alopecia

55 citations , February 1985 in “Archives of Dermatology”

Minoxidil applied twice daily can help regrow hair in some people with hereditary baldness, with no serious side effects.

research Epidermal growth factor delays the development of the epidermis and hair follicles of mice during growth of the first coat

72 citations , January 1983 in “The Anatomical Record”

Epidermal growth factor delays skin and hair development in mice.

Minoxidil in Resistant Hypertension

research Minoxidil in Resistant Hypertension

102 citations , September 1977 in “The Lancet”

Minoxidil with propranolol and diuretics lowers blood pressure but causes fluid retention and hair growth.

Related Research

2 / 2 results

research Keratinocyte Growth Factor Is an Important Endogenous Mediator of Hair Follicle Growth, Development, and Differentiation. Normalization of the Nu/Nu Follicular Differentiation Defect and Amelioration of Chemotherapy-Induced Alopecia.

219 citations , July 1995 in “PubMed”

Keratinocyte growth factor promotes hair growth and reduces hair loss from chemotherapy.

research Targeting Expression of Keratinocyte Growth Factor to Keratinocytes Elicits Striking Changes in Epithelial Differentiation in Transgenic Mice

265 citations , March 1993 in “The EMBO Journal”

Keratinocyte growth factor significantly alters skin and tissue development.