TLDR FGF and EGF are crucial for hair follicle development and growth.
The study investigated the roles of fibroblast growth factor (FGF) and epidermal growth factor (EGF) in hair follicle development in newborn mice. Daily injections of these growth factors for 1 week post-birth revealed that FGF influenced hair follicle initiation and development, causing a significant delay in hair cycles localized to the treatment area. Basic FGF (bFGF) was associated with mitotic activity in developing follicles, while acidic FGF (aFGF) was linked to follicle bulb differentiation. EGF, affecting the entire body coat, induced hyperkeratinization and delayed hair follicle development. These findings suggested that FGF and EGF play crucial roles in hair follicle morphogenesis through autocrine and paracrine mechanisms.
44 citations,
December 1991 in “Annals of the New York Academy of Sciences” EGF and FGF help hair growth by affecting cell differentiation and fiber growth.
65 citations,
October 1988 in “Clinics in dermatology” The dermal papilla interacts with the epidermis to control hair growth and development.
13 citations,
March 1988 in “Experientia” Anti-EGF serum affects growth and development in newborn mice.
58 citations,
January 1987 in “Archives of Dermatological Research” EGF and FGF boost hair cell growth, hydrocortisone slows it, and minoxidil doesn't affect it.
100 citations,
November 1996 in “Molecular Medicine Today” Growth factors and cytokines are important for hair growth and could potentially treat hair loss, but more research is needed to overcome challenges before they can be used in treatments.
1 citations,
January 2017 in “Elsevier eBooks” The document concludes that new treatments for hair loss may involve a combination of cosmetics, clinical methods, and genetic approaches.
90 citations,
October 1996 in “Dermatologic Clinics” Growth factors are crucial for hair development and could help treat hair diseases.
154 citations,
October 1996 in “Proceedings of the National Academy of Sciences of the United States of America” Estrogen affects hair growth and skin cell multiplication.
64 citations,
January 2015 in “BioMed Research International” Certain growth factors can promote hair growth in mice by activating hair growth-related proteins.
